Featured Research

from universities, journals, and other organizations

Lymphoma patients with cardiovascular disease have increased risk of cardiac hospitalization, study finds

Date:
July 2, 2010
Source:
American Society of Hematology
Summary:
Older patients with Hodgkin lymphoma (HL) and a history of heart disease face a high risk of hospitalization for cardiac complications after completing treatment, according to new research. HL is a form of cancer of arising in the lymph nodes, and approximately 8,500 people were diagnosed with the disease in 2009, according to the American Cancer Society.

Older patients with Hodgkin lymphoma (HL) and a history of heart disease face a high risk of hospitalization for cardiac complications after completing treatment, according to research published online in Blood, the journal of the American Society of Hematology.

Related Articles


HL is a form of cancer of arising in the lymph nodes, and approximately 8,500 people were diagnosed with the disease in 2009, according to the American Cancer Society.

Treatment for HL typically includes the drug doxorubicin as part of chemotherapy and may also include radiation therapy to lymph nodes in the chest. Although treatment produces high cure rates, these treatments can also be toxic to the heart. This makes treating patients with pre-existing heart disease particularly challenging.

To evaluate the toxicity of HL treatment, researchers collected data on hospitalizations for heart disease among 1,096 HL patients who had received common treatment regimens, including doxorubicin-containing chemotherapy and radiation therapy to lymph nodes in the chest.

The study found that the toxicity of different treatments varied significantly depending on whether patients had pre-existing heart disease. In particular, radiation therapy to the chest appeared to increase the risk of cardiac hospitalization to a much greater degree among those with pre-existing heart disease than among those without. Also, patients with heart disease whose treatment included radiation therapy to the chest were found to be approximately 2.5 times more likely to be hospitalized for cardiac reasons than those who were treated with chemotherapy alone.

"Efforts to reduce cardiac exposure to radiation in patients with pre-existing cardiac disease are warranted based on these findings," said David Hodgson, MD, David Hodgson, radiation oncologist at the Princess Margaret Hospital Cancer Program, University Health Network, investigator at the Institute of Clinical Evaluative Sciences, Ontario, Canada, and senior author of the study.

"However, the lower cardiac complication rate among patients treated only with chemotherapy occurred in part because they were more likely to die of other causes, so it is not a simple message that chemotherapy alone is better for all patients. Clinical trials are ongoing to more accurately identify which patients benefit from radiation therapy and to further reduce the administered dose to normal tissues," Hodgson said. "But oncologists need to be be aware of their patients' heart health and vigilant about post-treatment monitoring and active intervention to reduce their patients' cardiac risk factors."

Possible explanations for this relationship have been cited in animal studies that have shown that when an artery is exposed to radiation, inflammation appears in the arterial wall and can lead to the rupture of fatty deposits, which is a common cause of heart attacks in humans. This may, in part, explain the increased risk of heart problems following radiation therapy to the chest in patients who likely have such fatty deposits in their coronary arteries.


Story Source:

The above story is based on materials provided by American Society of Hematology. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Myrehaug, M. Pintilie, L. Yun, M. Crump, R. W. Tsang, R. M. Meyer, J. Sussman, E. Yu, D. C. Hodgson. A population-based study of cardiac morbidity among Hodgkin lymphoma patients with pre-existing heart disease. Blood, 2010; DOI: 10.1182/blood-2010-01-263764

Cite This Page:

American Society of Hematology. "Lymphoma patients with cardiovascular disease have increased risk of cardiac hospitalization, study finds." ScienceDaily. ScienceDaily, 2 July 2010. <www.sciencedaily.com/releases/2010/07/100702092203.htm>.
American Society of Hematology. (2010, July 2). Lymphoma patients with cardiovascular disease have increased risk of cardiac hospitalization, study finds. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2010/07/100702092203.htm
American Society of Hematology. "Lymphoma patients with cardiovascular disease have increased risk of cardiac hospitalization, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/07/100702092203.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins