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A risk factor of gallstone formation after radical gastrectomy

Date:
July 7, 2010
Source:
World Journal of Gastroenterology
Summary:
The incidence of gallstones is higher in patients after radical gastrectomy than in the general population. The current literature suggests that this higher incidence is related to gallbladder motility disorder after surgery. A research group in China investigated the association between the XbaI polymorphisms of APOB gene and gallstone formation after gastrectomy.
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The cause of higher incidence of gallstone after radical gastrectomy still remains unknown. Almost all previous studies have attributed gallstone formation to gallbladder motility disorder after gastrectomy, But this theory cannot completely explain it. Is there any other risk factor of gallstone formation after gastrectomy?

A research article to be published on May 28, 2010 in the World Journal of Gastroenterology addresses this question.

The research team led by Professor Niu from Zhongshan Hospital of Fudan University enrolled 206 patients between January 2005 and December 2006, who underwent radical gastrectomy for gastric cancer. These patients were grouped according to XbaI polymorphisms of APOB gene. After at least 2 years follow up, they found that the incidence of gallstone following gastrectomy was significiantly higher in patients with the X+ allele of APOB gene, who have a higher concentration of TC and LDL.

These results demonstrate that the X+ allele may influence the levels of TC and LDL, resulting in an increased saturation of bile cholesterol, leading to the gallstone formation after gastrectomy. The authors believe besides the gallbladder motility disorder, X+ allele of APOB gene is another important risk factor of gallstone formation after gastrectomy.


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The above post is reprinted from materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Liu FL, Lu WB, Niu WX. Xba%u2160 polymorphisms of apolipoprotein B gene: Another risk factor of gallstone formation after radical gastrectomy. World J Gastroenterol, 2010; 16 (20): 2549-2553 [link]

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World Journal of Gastroenterology. "A risk factor of gallstone formation after radical gastrectomy." ScienceDaily. ScienceDaily, 7 July 2010. <www.sciencedaily.com/releases/2010/07/100707093853.htm>.
World Journal of Gastroenterology. (2010, July 7). A risk factor of gallstone formation after radical gastrectomy. ScienceDaily. Retrieved August 30, 2015 from www.sciencedaily.com/releases/2010/07/100707093853.htm
World Journal of Gastroenterology. "A risk factor of gallstone formation after radical gastrectomy." ScienceDaily. www.sciencedaily.com/releases/2010/07/100707093853.htm (accessed August 30, 2015).

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