Featured Research

from universities, journals, and other organizations

Prediction tool helps estimate local recurrence in patients with noninvasive breast cancer

Date:
July 13, 2010
Source:
Memorial Sloan-Kettering Cancer Center
Summary:
In an attempt to help physicians and patients weigh the risks and benefits of the available options for treatment following breast-conserving surgery for patients diagnosed with ductal carcinoma in-situ, researchers have developed a new prediction tool that calculates a patient's individualized risk for recurrence five and ten years after surgery.

The decision regarding treatment following breast-conserving surgery for patients diagnosed with ductal carcinoma in-situ (DCIS) has long been an area of discussion and confusion for patients and physicians alike. While the mortality rates for DCIS remain low, the risk of local recurrence in the breast is high. Standard treatments following surgery include radiation therapy and hormone treatment. While both treatments have been proven to lower the risk of recurrence in the breast, neither has been shown to improve survival, and both carry potentially serious risks.

Related Articles


In an attempt to help physicians and patients weigh the risks and benefits of the available options, researchers from Memorial Sloan-Kettering Cancer Center (MSKCC) are reporting in the Journal of Clinical Oncology on the development of a new prediction tool that calculates a patient's individualized risk for recurrence five and ten years after surgery.

"For the first time, using readily available information, a patient and her oncologist can estimate her individualized risk, and then use this tool to help in the decision-making process regarding treatment options," said Kimberly Van Zee, MD, an attending surgeon in the Breast Cancer Surgical Service at Memorial Sloan-Kettering Cancer Center and the study's lead author. "To date, there has been no other way to integrate all of the known risk factors for recurrence and come up with an individualized absolute risk estimate. This nomogram will be a valuable tool in weighing the pros and cons of various treatments."

Today, approximately one in five new breast cancer cases will be diagnosed as DCIS, making non-invasive breast cancer the fourth most commonly diagnosed malignancy in women. In 2009, more than 67,000 new cases of DCIS were diagnosed in the United States. Experts cite increased use of screening methods such as mammography as the reason for the rise in case numbers.

In DCIS, cancer cells are confined to an area within the ducts of the breast and have not invaded surrounding breast tissue outside the ducts. Because DCIS is an early-stage breast cancer, survival following treatment for DCIS is about 98 percent. Paradoxically, however, the ten-year local breast recurrence rate is about 15 percent -- which is higher than the ten-year recurrence rate for women who have received breast-conserving treatment for invasive cancer. (Local recurrence is about 3 to 7 percent in women with invasive cancer who have received systemic therapy.)

Large, randomized clinical trials have shown that radiation after breast-conserving surgery decreases local breast recurrence by about half in patients with DCIS. However, radiation does not result in better survival and carries rare but serious potential risks. Therefore, most radiation oncologists do not recommend radiation to all women with DCIS -- rather, they attempt to identify those at lowest risk for recurrence and spare them radiation.

According to Dr. VanZee, until now, there has been no prediction tool to help doctors estimate the risk of recurrence and thus help identify which patients would benefit most from radiation therapy. As such, there is a need to generate an individualized estimate for the risk of recurrence when weighing the risks and benefits of said treatments. For example, in a woman at very high risk of recurrence, the added benefit of radiation and/or hormone treatments would be relatively large as compared to a woman at very low risk of recurrence.

In this study, researchers collected clinical and pathological data from 1,681 women who had breast-conserving surgery from 1991 to 2006 at MSKCC. The nomogram was built using ten variables, including the patient's age, family history, clinical presentation, margin status, and histopathological features such as nuclear grade and presence of necrosis -- all commonly available factors.

"Given that nomograms have been repeatedly shown to be more accurate at risk estimation than expert opinion, it is very helpful to have mathematical models to integrate available information and improve the decision-making process for our patients," said Dr. Van Zee.


Story Source:

The above story is based on materials provided by Memorial Sloan-Kettering Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Memorial Sloan-Kettering Cancer Center. "Prediction tool helps estimate local recurrence in patients with noninvasive breast cancer." ScienceDaily. ScienceDaily, 13 July 2010. <www.sciencedaily.com/releases/2010/07/100713165051.htm>.
Memorial Sloan-Kettering Cancer Center. (2010, July 13). Prediction tool helps estimate local recurrence in patients with noninvasive breast cancer. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2010/07/100713165051.htm
Memorial Sloan-Kettering Cancer Center. "Prediction tool helps estimate local recurrence in patients with noninvasive breast cancer." ScienceDaily. www.sciencedaily.com/releases/2010/07/100713165051.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins