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Starve a cancer: Calorie restriction as an anti-invasive therapy for malignant brain cancer

Date:
July 25, 2010
Source:
The Biochemical Society
Summary:
Researchers have found that reducing calorie intake can restrict the growth and spread of brain cancer.

Researchers at Boston College have found that reducing calorie intake can restrict the growth and spread of brain cancer.

Writing in ASN NEURO, Laura Shelton and colleagues report success with mice suffering from glioblastoma multiforme, the most aggressive and invasive form of primary human brain cancer.

Restricting calorific intake lowers blood glucose levels and reduces the carbohydrate energy available to the tumour cells, which rely heavily on glycolysis. Normal brain cells can use ketone bodies -- acetone, acetoacetic acid and β-hydroxybutyric acid -- for energy.

The researchers say that their findings "indicate that brain tumour cells are more sensitive to energy stress than normal brain cells and can be targeted through principles of metabolic control theory." They conclude that diets which lower glucose and elevate ketone levels can be therapeutic for invasive brain tumours.


Story Source:

The above story is based on materials provided by The Biochemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Laura Shelton, Leanne Huysentruyt, Purna Mukherjee, Thomas Seyfried. Calorie restriction as an anti-invasive therapy for malignant brain cancer in the VM mouse. ASN NEURO, 2010; DOI: 10.1042/AN20100002

Cite This Page:

The Biochemical Society. "Starve a cancer: Calorie restriction as an anti-invasive therapy for malignant brain cancer." ScienceDaily. ScienceDaily, 25 July 2010. <www.sciencedaily.com/releases/2010/07/100723112715.htm>.
The Biochemical Society. (2010, July 25). Starve a cancer: Calorie restriction as an anti-invasive therapy for malignant brain cancer. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2010/07/100723112715.htm
The Biochemical Society. "Starve a cancer: Calorie restriction as an anti-invasive therapy for malignant brain cancer." ScienceDaily. www.sciencedaily.com/releases/2010/07/100723112715.htm (accessed July 30, 2014).

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