Featured Research

from universities, journals, and other organizations

Fluorescent probe for oral cancer

Date:
August 4, 2010
Source:
University of California - Davis - Health System
Summary:
The probe stimulates molecules in the patient's tissues with a laser. Some of these molecules naturally respond by re-emitting fluorescent light. The device rapidly detects and analyzes this light using a process called "time-resolved fluorescence spectroscopy." By using sensitive measurements of the change in fluorescence over time, surgeons can see the tumor margins even as they are cutting the tissue.

UC Davis researchers have developed a laser probe for the early detection of oral cancer.
Credit: Image courtesy of University of California - Davis - Health System

UC Davis researchers have developed a laser probe for the early detection of oral cancer. A trial with human subjects shows that the device could also be used during surgery to locate the edges of a tumor.

Approximately 43,000 people in the U.S. are diagnosed with tumors of the mouth, pharynx and larynx each year. The main risk factor is smoking, but a recent rise in cases has been linked to human papillomavirus. Most cases are not diagnosed until the cancer has reached an advanced stage.

"There's a lot out there about breast, prostate and brain cancer, but people are not so aware about oral cancer and its devastating consequences," said Laura Marcu, a professor of biomedical engineering at UC Davis. "People don't think to look for it, and there isn't any routine screening."

Marcu's laboratory collaborated with Dr. Gregory Farwell's group in the Department of Otolaryngology at the UC Davis Cancer Center to develop the fiber-optic probe.

The probe stimulates molecules in the patient's tissues with a laser. Some of these molecules naturally respond by re-emitting fluorescent light. The device rapidly detects and analyzes this light using a process called "time-resolved fluorescence spectroscopy" (TR-LIFS), which provides information about the types of molecules present.

During surgery, blood can distort the intensity of the fluorescence signal but not its duration. By using sensitive measurements of the change in fluorescence over time, surgeons can see the tumor margins even as they are cutting the tissue.

Based on encouraging results in animal tests, Marcu and Farwell's team recruited nine human volunteers from among patients who arrived at the UC Davis Medical Center for surgical therapy of the mouth, throat and larynx. They compared readings from spectroscopy with biopsy samples from the same locations and found that the probe could accurately diagnose the cancer in the surgical environment.

The probe is similar to one that Marcu has already developed for use with brain tumors. In clinical trials, surgeons have used her technology to delineate the margins of tumors during surgery.

Details of the human oral cancer study will be published in an upcoming issue of the journal Otolaryngology -- Head and Neck Surgery. The pilot study in patients was supported in part by the Cancer Center and the Clinical and Translational Science Center at the UC Davis School of Medicine and the UC Davis Center for Biophotonics Science and Technology.


Story Source:

The above story is based on materials provided by University of California - Davis - Health System. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Davis - Health System. "Fluorescent probe for oral cancer." ScienceDaily. ScienceDaily, 4 August 2010. <www.sciencedaily.com/releases/2010/08/100804093207.htm>.
University of California - Davis - Health System. (2010, August 4). Fluorescent probe for oral cancer. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2010/08/100804093207.htm
University of California - Davis - Health System. "Fluorescent probe for oral cancer." ScienceDaily. www.sciencedaily.com/releases/2010/08/100804093207.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins