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Human neural stem cells restore motor function in mice with chronic spinal cord injury

Date:
August 20, 2010
Source:
University of California - Irvine
Summary:
Researchers have demonstrated that human neural stem cells can restore mobility in cases of chronic spinal cord injury, suggesting the prospect of treating a much broader population of patients.

Human neural stem cells transplanted into mice grew into neural tissue cells, such as oligodendrocytes.
Credit: Brian Cummings / UCI

A UC Irvine study is the first to demonstrate that human neural stem cells can restore mobility in cases of chronic spinal cord injury, suggesting the prospect of treating a much broader population of patients.

Previous breakthrough stem cell studies have focused on the acute, or early, phase of spinal cord injury, a period of up to a few weeks after the initial trauma when drug treatments can lead to some functional recovery.

The UCI study, led by Aileen Anderson and Brian Cummings of the Sue and Bill Gross Stem Cell Research Center, is significant because the therapy can restore mobility during the later chronic phase, the period after spinal cord injury in which inflammation has stabilized and recovery has reached a plateau. There are no drug treatments to help restore function in such cases.

The study appears in the open-access, peer-reviewed journal PLoS ONE and is available online.

The Anderson-Cummings team transplanted human neural stem cells into mice 30 days after a spinal cord injury caused hind-limb paralysis. The cells then differentiated into neural tissue cells, such as oligodendrocytes and early neurons, and migrated to spinal cord injury sites. Three months after initial treatment, the mice demonstrated significant and persistent recovery of walking ability in two separate tests of motor function when compared to control groups.

"Human neural stem cells are a novel therapeutic approach that holds much promise for spinal cord injury," said Anderson, associate professor of physical medicine & rehabilitation and anatomy & neurobiology at UCI. "This study builds on the extensive work we previously published in the acute phase of injury and offers additional hope to those who are paralyzed or have impaired motor function."

"About 1.3 million individuals in the U.S. are living with chronic spinal cord injury," added Cummings, associate professor of physical medicine & rehabilitation and anatomy & neurobiology. "This latest study provides additional evidence that human neural stem cells may be a viable treatment approach for them."

The research is the latest in a series of collaborative studies conducted since 2002 with StemCells Inc. that have focused on the use of StemCells' human neural stem cells in spinal cord injury and resulted in multiple co-authored publications. StemCells Inc., based in Palo Alto, Calif., is engaged in the research, development and commercialization of stem cell therapeutics and tools for use in stem cell-based research and drug discovery.

According to Dr. Stephen Huhn, vice president and head of the central nervous system program at StemCells Inc., "the strong preclinical data we have accumulated to date will enable our transition to a clinical trial, which we plan to initiate in 2011."

Desirιe Salazar of UC San Diego, Nobuko Uchida of StemCells Inc. and Frank P.T. Hamers of the Tolbrug Rehabilitation Centre in 's-Hertogenbosch, Netherlands, also contributed to the study, which received National Institutes of Health and California Institute for Regenerative Medicine support.


Story Source:

The above story is based on materials provided by University of California - Irvine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Desirιe L Salazar, Nobuko Uchida, Frank P T Hamers, Brian J Cummings, Aileen J Anderson. Human Neural Stem Cells Differentiate and Promote Locomotor Recovery in an Early Chronic Spinal coRd Injury NOD-scid Mouse Model. PLoS ONE, 2010; DOI: 10.1371/journal.pone.0012272

Cite This Page:

University of California - Irvine. "Human neural stem cells restore motor function in mice with chronic spinal cord injury." ScienceDaily. ScienceDaily, 20 August 2010. <www.sciencedaily.com/releases/2010/08/100819144440.htm>.
University of California - Irvine. (2010, August 20). Human neural stem cells restore motor function in mice with chronic spinal cord injury. ScienceDaily. Retrieved September 3, 2014 from www.sciencedaily.com/releases/2010/08/100819144440.htm
University of California - Irvine. "Human neural stem cells restore motor function in mice with chronic spinal cord injury." ScienceDaily. www.sciencedaily.com/releases/2010/08/100819144440.htm (accessed September 3, 2014).

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