Featured Research

from universities, journals, and other organizations

Human umbilical cord blood cells aid lab animal brain cell survival after simulated stroke

Date:
August 24, 2010
Source:
University of South Florida (USF Health)
Summary:
When human umbilical cord blood cells were used to treat cultured rat brain cells deprived of oxygen, the cells appeared to protect astrocytes from cell death after stroke-like damage. Researchers found that cord blood cells stabilized the brain cell environment and aided astrocyte survival.

Human umbilical cord blood cells (HUCB) used to treat cultured rat brain cells (astrocytes) deprived of oxygen appear to protect astrocytes from cell death after stroke-like damage, reports a team of researchers from the University of South Florida (USF) Department of Neurosurgery and Brain Repair.

Their study was published in the August, 2010 issue of Stem Cell Review and Reports.

The USF study was carried out with astrocytes cultured in the laboratory (in vitro) and then subjected to oxygen deprivation (hypoxia) and glucose deprivation to model what happens in the human brain during a stroke.

Astrocytes, star-shaped cells in the brain and spinal cord, perform several functions, including support of cells that make up the blood-brain barrier separating circulating blood and spinal fluid.

"When we compared survival of astrocytes grown with and without human umbilical cord blood cells during a period of hypoxia and reduced nutrients, we found that the cord blood cells stabilized the brain cell environment and aided astrocyte survival," said lead author and professor Alison Willing, PhD. "However, the cord blood cells also had an impact on cytokines -- small proteins secreted by cells of the immune system -- and also on glial cells that carry signals between cells."

The researchers discovered that the HUCBs changed cytokine "expression" -- sometimes suppressing inflammation and other times enhancing it.

"The effects of cord blood cells on astrocytes are not clear and more research is needed to clarify the issue," said Dr. Willing. "HUCBs are composed of different types of immune cells and have the ability to secrete both pro- and anti-inflammatory cytokines. This suggests that the cells may promote recovery following stroke by regulating inflammatory responses and providing support for neural cells, such as astrocytes."

"Our data demonstrated that the different types of HUCBs alone do not enhance astrocyte survival," concluded Dr. Willing. "This result suggests that either another cell component is neuroprotective, or the interaction of all cell types within the entire HUCB population aids protection."


Story Source:

The above story is based on materials provided by University of South Florida (USF Health). Note: Materials may be edited for content and length.


Journal Reference:

  1. Lixian Jiang, Samuel Saporta, Ning Chen, Cyndy Davis Sanberg, Paul Sanberg, Alison Willing. The Effect of Human Umbilical Cord Blood Cells on Survival and Cytokine Production by Post-Ischemic Astrocytes in Vitro. Stem Cell Reviews and Reports, 2010; DOI: 10.1007/s12015-010-9174-x

Cite This Page:

University of South Florida (USF Health). "Human umbilical cord blood cells aid lab animal brain cell survival after simulated stroke." ScienceDaily. ScienceDaily, 24 August 2010. <www.sciencedaily.com/releases/2010/08/100824103529.htm>.
University of South Florida (USF Health). (2010, August 24). Human umbilical cord blood cells aid lab animal brain cell survival after simulated stroke. ScienceDaily. Retrieved April 25, 2014 from www.sciencedaily.com/releases/2010/08/100824103529.htm
University of South Florida (USF Health). "Human umbilical cord blood cells aid lab animal brain cell survival after simulated stroke." ScienceDaily. www.sciencedaily.com/releases/2010/08/100824103529.htm (accessed April 25, 2014).

Share This



More Health & Medicine News

Friday, April 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins