Featured Research

from universities, journals, and other organizations

Fat distribution plays a role in weight loss success in patients at risk of diabetes

Date:
August 26, 2010
Source:
Radiological Society of North America
Summary:
Why is it that some people lose weight and body fat when they exercise and eat less and others don't? Researchers say MRI and magnetic resonance spectroscopy can provide the answer -- and help predict who will benefit from lifestyle changes.

Why is it that some people lose weight and body fat when they exercise and eat less and others don't? German researchers say MRI and magnetic resonance (MR) spectroscopy can provide the answer -- and help predict who will benefit from lifestyle changes. Results of the study are published online and will appear in the November issue of the journal Radiology.

Related Articles


"You may have two individuals who weigh the same and have the same body mass index (BMI), but have very different levels of internal fat," said lead researcher and physicist Jürgen Machann, Dipl. Phys., from University Hospital Tübingen in Tübingen, Germany. "Abdominal and liver fat are the two most important factors in predicting whether a lifestyle intervention will be successful."

Machann and researchers performed MRI and MR spectroscopy on 243 individuals prior to and nine months after a lifestyle intervention. The intervention called for a weight loss of 5 percent, reducing fat intake to a maximum of 30 percent of total calories (including less than 10 percent in the form of saturated fat) and engaging in moderate physical activity such as walking at least three hours a week.

Each of the participants, which included 144 females (mean age 44.5 years) and 99 males (mean age 47.3), was considered at risk of developing type 2 diabetes as a result of obesity, measured by a body mass index (BMI) of 27 or greater or having an impaired glucose tolerance or a first-degree relative with the disease.

"Common methods, such as body impedance analysis, may determine that a body consists of 25 percent fat, but that does not tell you how the fat is distributed," Machann said. "BMI is a good measure for obesity but not necessarily a predictor for health risk, because not only the amount of fat, but also its distribution are essential. Only by looking inside the body can you establish the amount of visceral (abdominal) and liver fat."

MRI allowed researchers to differentiate fatty tissue from lean tissue throughout the body. MR spectroscopy generated additional data on the fat content of individual organs, such as the liver.

Researchers used improved insulin sensitivity to measure the success of the lifestyle intervention. Individuals with type 2 diabetes do not respond correctly to insulin, a hormone secreted by the pancreas that aids in metabolism. In pre-diabetes, cells become resistant to the action of insulin.

After nine months of participating in the lifestyle intervention, insulin sensitivity improved in 71 percent of the men and 58 percent of the women. Individuals with improved insulin sensitivity lost significant amounts of visceral fat (a mean reduction of 19 percent for women and 20 percent for men) and liver fat (a mean reduction of 35 percent for women and 44 percent for men) while reducing 3 to 5 percent of body weight.

"The participants who improved their health status as a result of diet and exercise started out with lower baseline levels of abdominal and liver fat," Machann said. "In our study, these two factors predetermined whether or not a lifestyle intervention would be successful for a particular individual."

Individuals who did not improve insulin sensitivity as a result of lifestyle changes lost much smaller amounts of visceral fat (a mean reduction of 4 percent for women and 6 percent for men). The men also lost less liver fat (a mean of 15 percent), and women gained a mean of 22 percent in liver fat.

"Our results demonstrate that with MRI and MR spectroscopy, we can determine who will benefit from dietary changes and exercise and who will need other interventions," Machann said.


Story Source:

The above story is based on materials provided by Radiological Society of North America. Note: Materials may be edited for content and length.


Journal Reference:

  1. Machann et al. Follow-up Whole-Body Assessment of Adipose Tissue Compartments during a Lifestyle Intervention in a Large Cohort at Increased Risk for Type 2 Diabetes. Radiology, 2010; DOI: 10.1148/radiol.10092284

Cite This Page:

Radiological Society of North America. "Fat distribution plays a role in weight loss success in patients at risk of diabetes." ScienceDaily. ScienceDaily, 26 August 2010. <www.sciencedaily.com/releases/2010/08/100824132355.htm>.
Radiological Society of North America. (2010, August 26). Fat distribution plays a role in weight loss success in patients at risk of diabetes. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2010/08/100824132355.htm
Radiological Society of North America. "Fat distribution plays a role in weight loss success in patients at risk of diabetes." ScienceDaily. www.sciencedaily.com/releases/2010/08/100824132355.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins