Featured Research

from universities, journals, and other organizations

Bone hormone levels linked to risk of death for patients with heart failure

Date:
September 1, 2010
Source:
European Society of Cardiology (ESC)
Summary:
Patients suffering with heart failure are more likely to die if they have high levels of a bone hormone called osteoprotegerin (OPG). That is the finding of a research team from the Akershus University Hospital and the University of Oslo in Norway, in collaboration with colleagues in Italy and Denmark.

Patients suffering with heart failure are more likely to die if they have high levels of a bone hormone called osteoprotegerin (OPG). That is the finding of a research team from the Akershus University Hospital and the University of Oslo in Norway, in collaboration with colleagues in Italy and Denmark.

Related Articles


The research is being presented at the European Society of Cardiology's Congress 2010 in Stockholm.

Heart failure currently affects 14 million people in Europe, and is an increasing health problem. It develops when the heart is not able to deliver sufficient amounts of oxygenated blood to the rest of the body.

Previous research has speculated that the OPG hormone, which is thought to prevent the loss of bone tissue, might be linked to heart failure. According to Professor Torbjψrn Omland of the University of Oslo: "Studies using mice have demonstrated that reduction in OPG levels can lead to the development of osteoporosis, but also cause calcification of the major blood vessels. And in humans, it has been observed that calcification of blood vessels is frequently accompanied by the loss of bone tissue. Paradoxically, however, while animal studies suggest that increased levels of OPG protect the blood vessels, human studies suggest that high levels are associated with adverse outcome after myocardial infarction, a common precursor of heart failure"

Because this link between OPG and heart failure is unclear, the study set out to properly address the prognostic implications of OPG in patients with chronic heart failure. OPG levels were measured in blood samples from 1,229 patients with chronic heart failure. These patients were participating in the Italian GISSI-HF trial (Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico -- HF), and they were followed for an average of 3.9 years. The results showed that patients with the highest 1/3 levels of OPG were twice as likely to die during follow-up, than the patients with the lowest 1/3 levels of OPG.

Professor Omland, a co-author of the study concluded: "The finding is interesting not only because it suggests that there is a link between bone metabolism and heart disease, but because it might help to identify heart failure patients who are at greatest risk. As medical practitioners, we can then target those patients earlier with intensified therapy."


Story Source:

The above story is based on materials provided by European Society of Cardiology (ESC). Note: Materials may be edited for content and length.


Cite This Page:

European Society of Cardiology (ESC). "Bone hormone levels linked to risk of death for patients with heart failure." ScienceDaily. ScienceDaily, 1 September 2010. <www.sciencedaily.com/releases/2010/08/100831122059.htm>.
European Society of Cardiology (ESC). (2010, September 1). Bone hormone levels linked to risk of death for patients with heart failure. ScienceDaily. Retrieved January 28, 2015 from www.sciencedaily.com/releases/2010/08/100831122059.htm
European Society of Cardiology (ESC). "Bone hormone levels linked to risk of death for patients with heart failure." ScienceDaily. www.sciencedaily.com/releases/2010/08/100831122059.htm (accessed January 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, January 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Poultry Culled in Taiwan to Thwart Bird Flu

Poultry Culled in Taiwan to Thwart Bird Flu

Reuters - News Video Online (Jan. 28, 2015) — Taiwan culls over a million poultry in efforts to halt various strains of avian flu. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
Media Criticizing Parents For Not Vaccinating Children

Media Criticizing Parents For Not Vaccinating Children

Newsy (Jan. 28, 2015) — As the Disneyland measles outbreak continues to spread, the media says parents who choose not to vaccinate their children are part of the cause. Video provided by Newsy
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) — A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com
Shoveling Snow: How to Prevent Back Injuries

Shoveling Snow: How to Prevent Back Injuries

Washington Post (Jan. 26, 2015) — What&apos;s the proper technique for shoveling snow? A physical therapist offers specific tips for protecting your back while you dig out this winter. Video provided by Washington Post
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins