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Why females fare better than males after traumatic injury

Date:
September 1, 2010
Source:
Scott & White Healthcare
Summary:
A new study looks at how female versus male rats fared after suffering a trauma and subsequent hemorrhagic shock who were given Estradiol (estrogen). In the study, the Estradiol prevented vascular permeability following hemorrhagic shock.

A new study looks at how female versus male rats fared after suffering a trauma and subsequent hemorrhagic shock who were given Estradiol (estrogen).

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In the study, published in the September 2010 issue of Shock by Dr. Ed W. Childs and colleagues at Scott & White Healthcare, the Estradiol prevented vascular permeability following hemorrhagic shock.

"We've always known that females fare better than males after traumatic injury, but we never knew why, now we know a potential mechanism," said Ed W. Childs, M.D., professor of surgery at the Texas A&M Health Science Center College of Medicine, and vice chairman of research in the department of surgery at Scott & White Healthcare.

"This study proved that estrogen receptors on the mitochondria of our cells actually help protect these cells on females after injury. But, if you block those estrogen receptors, they perform like those of a male."

Examples of shock can include: car accident, falls that may include a severe trauma, and any injury that causes bleeding. Shock (level IV) is defined as 40% blood volume loss and a systolic blood pressure under 90.


Story Source:

The above story is based on materials provided by Scott & White Healthcare. Note: Materials may be edited for content and length.


Journal Reference:

  1. Childs, EW, Tharakan B, Hunter FA, Smythe WR. 17β-estradiol mediated protection against vascular leak after hemorrhagic shock: role of estrogen receptors and apoptotic signaling. Shock, 2010; 34 (3): 229-35 DOI: 10.1097/SHK.0b013e3181d75b50

Cite This Page:

Scott & White Healthcare. "Why females fare better than males after traumatic injury." ScienceDaily. ScienceDaily, 1 September 2010. <www.sciencedaily.com/releases/2010/08/100831172128.htm>.
Scott & White Healthcare. (2010, September 1). Why females fare better than males after traumatic injury. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2010/08/100831172128.htm
Scott & White Healthcare. "Why females fare better than males after traumatic injury." ScienceDaily. www.sciencedaily.com/releases/2010/08/100831172128.htm (accessed October 31, 2014).

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