Featured Research

from universities, journals, and other organizations

New infrared light may open new frontier in fighting cancer, Tay Sachs

Date:
September 2, 2010
Source:
University of Central Florida
Summary:
A "game-changing" technique using near infrared light enables scientists to look deeper into the guts of cells, potentially opening up a new frontier in the fights against cancer and many other diseases.

A "game-changing" technique using near infrared light enables scientists to look deeper into the guts of cells, potentially opening up a new frontier in the fights against cancer and many other diseases.

Related Articles


University of Central Florida chemists, led by Professor Kevin Belfield, used near infrared light and fluorescent dye to take pictures of cells and tumors deep within tissue. The probes specifically target lysosomes, which act as cells' thermostats and waste processors and which have been linked to a variety of diseases, including types of mental illnesses and cancers.

The probes can be adapted to search for certain proteins found in tumors, which means they someday may help doctors diagnose and potentially treat tumors.

"This is a game-changer," Belfield said. "Until now, there was no real way to study lysosomes because existing techniques have severe limitations. But the probe we developed is stable, which allows for longer periods of imaging."

Current imaging probes work for only a few minutes. They cannot penetrate deep tissue, are sensitive to pH levels and have poor water solubility. Belfield's technique gets around those problems by using near infrared light. Once researchers identified the correct light frequency, they took images of lysosomes for hours.

The new approach will allow researchers to see lysosomes at work and to piece together their role in diseases such as cancer and Tay-Sachs, a genetic disorder from which children typically die by age 4.

"We've come up with something that should make a huge difference in finding answers to some very complicated conditions," Belfield said.

Belfield's findings, which include comparisons to the only two existing probes on the market today, are published in this month's Journal of the American Chemical Society, one of the most highly ranked journals in chemistry.

Belfield published three other papers this summer looking at probes that were adapted to search for proteins found in tumors. Those articles were published in Organic and Biomolecular Chemistry and the Journal of Organic Chemistry.

The National Institutes of Health's National Institute for Biomedical Imaging and Bioengineering funded the project.

Belfield's team is continuing its research with NIH funding. The UCF researchers are working with the Sanford-Burnham Institute for Medical Research on the tests required before clinical studies can begin.


Story Source:

The above story is based on materials provided by University of Central Florida. Note: Materials may be edited for content and length.


Cite This Page:

University of Central Florida. "New infrared light may open new frontier in fighting cancer, Tay Sachs." ScienceDaily. ScienceDaily, 2 September 2010. <www.sciencedaily.com/releases/2010/09/100901072957.htm>.
University of Central Florida. (2010, September 2). New infrared light may open new frontier in fighting cancer, Tay Sachs. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2010/09/100901072957.htm
University of Central Florida. "New infrared light may open new frontier in fighting cancer, Tay Sachs." ScienceDaily. www.sciencedaily.com/releases/2010/09/100901072957.htm (accessed October 25, 2014).

Share This



More Matter & Energy News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
Real-Life Transformer Robot Walks, Then Folds Into a Car

Real-Life Transformer Robot Walks, Then Folds Into a Car

Buzz60 (Oct. 24, 2014) Brave Robotics and Asratec teamed with original Transformers toy company Tomy to create a functional 5-foot-tall humanoid robot that can march and fold itself into a 3-foot-long sports car. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com
Police Testing New Gunfire Tracking Technology

Police Testing New Gunfire Tracking Technology

AP (Oct. 24, 2014) A California-based startup has designed new law enforcement technology that aims to automatically alert dispatch when an officer's gun is unholstered and fired. Two law enforcement agencies are currently testing the technology. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins