Featured Research

from universities, journals, and other organizations

Regular statin use is associated with a reduced risk of developing rheumatoid arthritis

Date:
September 8, 2010
Source:
Public Library of Science
Summary:
There is an association between taking statins (lipid lowering drugs), and reduced risk of developing the chronic inflammatory disease, rheumatoid arthritis.

There is an association between taking statins (lipid lowering drugs), and reduced risk of developing the chronic inflammatory disease, rheumatoid arthritis. These are the findings of a study by Gabriel Chodick and colleagues, published in this week's PLoS Medicine.

Related Articles


The researchers conducted a retrospective cohort study among the 1.8-million members of Maccabi Healthcare Services (a health maintenance organization [HMO]) in Israel to identify adults who regularly took statins and did not have rheumatoid arthritis. Using Maccabi's large automated datasets, the researchers then analyzed diagnostic codes to assess the incidence of newly diagnosed rheumatoid arthritis in this group between 1998 and 2007. To assess any potential bias, the researchers also examined any possible association between persistent statin use and the development of osteoarthritis, a common degenerative joint disease that is unlikely to be affected by statin use.

During the study follow-up period, there were 2,578 incident cases of rheumatoid arthritis and 17,878 incident cases of osteoarthritis. The unadjusted rate of rheumatoid arthritis among patients who did not persistently take statins was 51% higher than that of patients who used statins for at least 80% of the follow-up period. After adjusting for other possible confounders, patients who persistently took statins had a lower risk (risk ratio of 0.58) of developing rheumatoid arthritis compared with patients who did not persistently take statins. There was only a small short term decrease in risk ratio in patients taking statins and the development of osteoarthritis. (hazard ratio of 0.85)

This work needs to be confirmed in other populations before its clinical significance, if any, is clear. As the authors conclude: "Larger, systematic, controlled, prospective studies with high efficacy statins, particularly in younger adults who are at increased risk of rheumatoid arthritis, are needed to confirm these findings and to clarify the exact nature of the biological relationship between adherence to statin therapy and the incidence of rheumatoid arthritis."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chodick et al. Persistence with Statins and Onset of Rheumatoid Arthritis: A Population-Based Cohort Study. PLoS Medicine, 2010; 7 (9): e1000336 DOI: 10.1371/journal.pmed.1000336

Cite This Page:

Public Library of Science. "Regular statin use is associated with a reduced risk of developing rheumatoid arthritis." ScienceDaily. ScienceDaily, 8 September 2010. <www.sciencedaily.com/releases/2010/09/100907171634.htm>.
Public Library of Science. (2010, September 8). Regular statin use is associated with a reduced risk of developing rheumatoid arthritis. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2010/09/100907171634.htm
Public Library of Science. "Regular statin use is associated with a reduced risk of developing rheumatoid arthritis." ScienceDaily. www.sciencedaily.com/releases/2010/09/100907171634.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins