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Research and insights on severe asthma in children

Date:
September 9, 2010
Source:
Mary Ann Liebert, Inc./Genetic Engineering News
Summary:
A subset of children with asthma suffers from severe, treatment-resistant disease associated with more illness and greater allergic hypersensitivity, according to recent research.

A subset of children with asthma suffers from severe, treatment-resistant disease associated with more illness and greater allergic hypersensitivity, according to the results of the National Heart, Blood, and Lung Institute's Severe Asthma Research Program (SARP), presented in a recently published article in Pediatric Allergy, Immunology, and Pulmonology, a peer-reviewed journal published by Mary Ann Liebert, Inc.

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Asthma is the most common chronic lung disease of children, with more than 6.6 million affected in the U.S. Although relatively few children have severe asthma, they account for almost half of asthma related expenditures.

SARP compared severe, therapy-resistant asthma in children and adults and identified age-specific characteristics of the disease. The results suggest that there are distinguishable clinical features of severe asthma that can be identified early in life. Authors Anne Fitzpatrick, PhD from Emory University (Atlanta, GA) and William Gerald Teague, MD from the University of Virginia (Charlottesville) review the highlights of the SARP findings in an article entitled "Severe Asthma in Children: Insights from the National Heart, Lung, and Blood Institute's Severe Asthma Research Program." They conclude that children with severe, therapy-resistant asthma are more likely to have poorer lung function and higher levels of allergic sensitization and to be of African American or mixed ancestry. Their findings suggest that children as young as 6 years with severe asthma may already have structural airway changes.

"Identifying the features associated with severe, treatment-resistant asthma in children will allow us to better understand this illness and develop better treatments for these children who spend so much time struggling to breathe," says Harold Farber, MD, MSPH, Editor of Pediatric Allergy, Immunology, and Pulmonology, and Associate Professor of Pediatrics, Section of Pulmonology, Baylor College of Medicine, Houston, TX.


Story Source:

The above story is based on materials provided by Mary Ann Liebert, Inc./Genetic Engineering News. Note: Materials may be edited for content and length.


Journal Reference:

  1. Anne M. Fitzpatrick, William Gerald Teague. Severe Asthma in Children: Insights from the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Pediatric Allergy, Immunology, and Pulmonology, 2010; 23 (2): 131-138 DOI: 10.1089/ped.2010.0021

Cite This Page:

Mary Ann Liebert, Inc./Genetic Engineering News. "Research and insights on severe asthma in children." ScienceDaily. ScienceDaily, 9 September 2010. <www.sciencedaily.com/releases/2010/09/100909114123.htm>.
Mary Ann Liebert, Inc./Genetic Engineering News. (2010, September 9). Research and insights on severe asthma in children. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2010/09/100909114123.htm
Mary Ann Liebert, Inc./Genetic Engineering News. "Research and insights on severe asthma in children." ScienceDaily. www.sciencedaily.com/releases/2010/09/100909114123.htm (accessed October 24, 2014).

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