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Protein may advance Parkinson's by preventing neurons from clearing debris

Date:
September 28, 2010
Source:
Rockefeller University Press
Summary:
A protein linked to Parkinson's disease may cause neurodegeneration by inhibiting autophagy -- the process in which cells digest some of their contents -- according to a new study.
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An abundance of alpha-synuclein (right) reduces the number of autophagosomes (bright puncta, left), the double-membraned vesicles that remove trash from the cell. Blocking autophagosome formation in this way may contribute to neurodegeneration in Parkinson’s patients.
Credit: Winslow, A.R., et al. 2010. J. Cell Biol. doi:10.1083/jcb.201003122.

A protein linked to Parkinson's disease may cause neurodegeneration by inhibiting autophagy -- the process in which cells digest some of their contents -- according to a study in the September 20 issue of the Journal of Cell Biology.

Autophagy serves to clear a variety of toxic waste from cells, including misfolded proteins and defective mitochondria. These two types of cellular trash accumulate in neurons from Parkinson's patients, suggesting that autophagy could be impaired in these cells. A commonly amassed protein in Parkinson's disease is alpha-synuclein, whose gene is often mutated or overexpressed in familial forms of the illness. David Rubinsztein and researchers from the University of Cambridge in England found that excess alpha-synuclein inhibits autophagy by blocking formation of the autophagosome -- the double-membraned vesicle that engulfs cytoplasmic garbage and delivers it to lysosomes for destruction.

Previous research revealed that alpha-synuclein inhibits Rab1a, a small GTPase that controls secretory transport from the Endoplasmic Reticulum to the Golgi. Rubinsztein and colleagues now provide new insight into the role Rab1a plays in autophagy, and why blocking it has such dire consequences. The team found that lack of Rab1a impaired autophagosome formation, whereas an abundance of the GTPase reversed the inhibitory effects of alpha-synuclein on autophagy. Rab1a and alpha-synuclein act specifically at an early stage of autophagosome formation: an abundance of alpha-synuclein or lack of Rab1a disrupted an early acting part of the autophagy machinery called Atg9 and blocked the formation of autophagosome precursors known as omegasomes.

Alpha-synuclein's blockade of autophagy could enhance the gradual accumulation of toxic proteins and dysfunctional mitochondria, sensitizing neurons to cell death.


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The above post is reprinted from materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. R. Winslow, C.-W. Chen, S. Corrochano, A. Acevedo-Arozena, D. E. Gordon, A. A. Peden, M. Lichtenberg, F. M. Menzies, B. Ravikumar, S. Imarisio, S. Brown, C. J. O'Kane, D. C. Rubinsztein.  -Synuclein impairs macroautophagy: implications for Parkinson's disease. The Journal of Cell Biology, 2010; 190 (6): 1023 DOI: 10.1083/jcb.201003122

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Rockefeller University Press. "Protein may advance Parkinson's by preventing neurons from clearing debris." ScienceDaily. ScienceDaily, 28 September 2010. <www.sciencedaily.com/releases/2010/09/100920123544.htm>.
Rockefeller University Press. (2010, September 28). Protein may advance Parkinson's by preventing neurons from clearing debris. ScienceDaily. Retrieved July 7, 2015 from www.sciencedaily.com/releases/2010/09/100920123544.htm
Rockefeller University Press. "Protein may advance Parkinson's by preventing neurons from clearing debris." ScienceDaily. www.sciencedaily.com/releases/2010/09/100920123544.htm (accessed July 7, 2015).

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