Featured Research

from universities, journals, and other organizations

New stent design demonstrates superiority at six months

Date:
September 21, 2010
Source:
Cardiovascular Research Foundation
Summary:
A new drug-eluting stent design demonstrated superiority over a traditional drug-eluting stent at 6 months, according to a new study.

A new drug-eluting stent design demonstrated superiority over a traditional drug-eluting stent at 6 months, according to a study led by Laura Mauri, MD, Associate Professor of Medicine, Brigham and Women's Hospital, Harvard Medical School (Boston, MA.) The study is being presented at the 22nd annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation.

Related Articles


"This new stent proved superior to a traditional drug-eluting stent for the primary endpoint of in-stent late loss at 6 months. This was associated with a trend for better clinical outcomes and an absence of stent thrombosis. The bioresorbable polymer and stent design are targeted to mitigate thrombosis risk without compromising anti-restenotic efficacy," said Dr. Mauri.

Traditional drug eluting stents (DES) deliver an anti-proliferative drug to the vessel wall from a durable polymer which homogeneously covers the outer surface of the stent. The stent used in this study is a sirolimus-eluting coronary stent system that combines a bioresorbable PLGA polymer with the antiproliferative agent sirolimus within a novel reservoir technology on a chromium-cobalt stent platform, reducing spatial and temporal polymer exposure. After drug and polymer reabsorption, all that remains is an inert metallic stent.

Eligible patients had single de-novo lesions ≤28mm in native coronary arteries 2.5 -- 3.5mm. The primary endpoint was in-stent late loss (LL) at 6 months. Secondary endpoints included death, myocardial infarction (MI), clinically driven target lesion (TLR) and target vessel revascularization (TVR) and the composite endpoints MACE (death, MI, TLR), target lesion failure (cardiac death, target vessel-related MI, TLR), and ARC adjudicated stent thrombosis (ST). IVUS was performed in a subgroup of 100 patients. Clinical follow-up is to be completed at 1, 6, and 12 months and annually to 5 years. Angiographic follow-up was performed at 6 months.

A total of 394 patients were enrolled at 40 sites in 9 countries from March to October 2008. The primary endpoint, in-stent LL at 6 months, (0.13±0.31mm for NEVO™ and 0.36±0.48mm for TAXUS® Liberté) reached statistical significance for the non-inferiority and superiority hypothesis (P < 0.001). Superiority was also demonstrated for the pre-defined subgroups of diabetes, stent diameter, and lesion length < or > 20mm. While not powered for clinical endpoints, 6 month outcomes showed lower event rates for the NEVO™ group: death (0.5% vs. 1.6%, P=0.36); MI (2.0% vs. 2.6%, P=0.75); TLR (1.5% vs. 3.7%, P=0.21); MACE (4.0% vs. 7.9%, P=0.13.) No stent thrombosis was observed for NEVO™, while 2 cases occurred in the TAXUS® group. IVUS showed lower neointimal volume for NEVO™ (5.8±11.7mm3 vs 19.5±24.7mm3, P=0.004).

12-month outcome data will be presented be during the Drug-Eluting and Bare Metal Stent Studies I Oral Abstract Session on September 22 at the Washington Convention Center.


Story Source:

The above story is based on materials provided by Cardiovascular Research Foundation. Note: Materials may be edited for content and length.


Cite This Page:

Cardiovascular Research Foundation. "New stent design demonstrates superiority at six months." ScienceDaily. ScienceDaily, 21 September 2010. <www.sciencedaily.com/releases/2010/09/100921084543.htm>.
Cardiovascular Research Foundation. (2010, September 21). New stent design demonstrates superiority at six months. ScienceDaily. Retrieved March 3, 2015 from www.sciencedaily.com/releases/2010/09/100921084543.htm
Cardiovascular Research Foundation. "New stent design demonstrates superiority at six months." ScienceDaily. www.sciencedaily.com/releases/2010/09/100921084543.htm (accessed March 3, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 3, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) — Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) — If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) — GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) — How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins