Featured Research

from universities, journals, and other organizations

Genetic factor in osteoporosis discovered

Date:
September 23, 2010
Source:
Plataforma SINC
Summary:
Spanish researchers have confirmed there is a genetic risk factor for osteoporosis and bone fractures. Although more studies are still needed, these findings will make it possible to take preventive measures.

Spanish researchers have confirmed there is a genetic risk factor for osteoporosis and bone fractures. Although more studies are still needed, these findings will make it possible to take preventive measures.

Related Articles


Scientists from the University of Barcelona (UB) have discovered that the genetic variant 677C>T (a single nucleotide polymorphism (SNP) that is very well known in genetic studies) is linked to osteoporotic vertebral fractures, which many women suffer from after the menopause.

"In this genetic variant, the women that displayed a TT combination (or genotype) had double the risk of suffering from osteoporotic fractures than women with the other possible combinations (CT and CC)," say Susana Balcells and Daniel Grinberg, lead authors of the study and researchers at the UB.

The new study, published in the journal Calcified Tissue International, reveals that osteoporotic vertebral fractures can now be added to the list of illnesses (including Alzheimer's disease and cardiovascular disease) that are related to 677C>T.

The problem is that the variant confirmed is one of perhaps 100 that entail a heightened risk of osteoporosis. Analysing them individually is of limited predictive value, and experiments need to be carried out. "This is why we're asking diagnostic laboratorios to be prudent," the authors explain.

SNPs are polymorphisms that affect a single nucleotide in the DNA sequence. There are two possible versions in human populations (alleles) for each SNP. In order to find genetic factors linked to susceptibility to common illnesses, these variants must be analysed. There are around 10 million SNPs in the human genome, spread throughout all the chromosomes.

Anyone can break a hip

Osteoporosis is the most common form of bone disease. The human organism is not able to build enough new bone, and old bone is absorbed by the body. One in every three women and one in every 12 men aged over 50 have osteoporosis, an illness that causes millions of bone fractures each year. Post-menopausal women, who have reduced levels of oestrogen and other hormonal deficits, are most at risk.

Bone loss starts from the age of 35. Calcium and vitamin D deficiency, tobacco, alcohol and caffeine consumption and a sedentary lifestyle all raise the risk of osteoporosis. According to the experts, sports and calcium supplements before the menopause can help to maintain bone mass. In some cases, hormonal patches can be used, as long as this is done under strict gynaecological supervision.


Story Source:

The above story is based on materials provided by Plataforma SINC. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lídia Agueda, Roser Urreizti, Mariona Bustamante, Susana Jurado, Natàlia Garcia-Giralt, Adolfo Díez-Pérez, Xavier Nogués, Leonardo Mellibovsky, Daniel Grinberg, Susana Balcells. Analysis of Three Functional Polymorphisms in Relation to Osteoporosis Phenotypes: Replication in a Spanish Cohort. Calcified Tissue International, 2010; 87 (1): 14 DOI: 10.1007/s00223-010-9361-4

Cite This Page:

Plataforma SINC. "Genetic factor in osteoporosis discovered." ScienceDaily. ScienceDaily, 23 September 2010. <www.sciencedaily.com/releases/2010/09/100922082333.htm>.
Plataforma SINC. (2010, September 23). Genetic factor in osteoporosis discovered. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2010/09/100922082333.htm
Plataforma SINC. "Genetic factor in osteoporosis discovered." ScienceDaily. www.sciencedaily.com/releases/2010/09/100922082333.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) — Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Diné Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins