Featured Research

from universities, journals, and other organizations

Absent mothers can cause hyperactivity and anxiety in offspring later in life, mouse study finds

Date:
September 29, 2010
Source:
BioMed Central
Summary:
In mice, early weaning and separation from their mothers promotes long-lasting hyperactivity and anxiety. Researchers describe the development of this new behavioral model, which they hope to use to investigate the long-term effects of early childhood neglect in people.

In mice, early weaning and separation from their mothers promotes long-lasting hyperactivity and anxiety . Researchers writing in the open access journal BMC Neuroscience describe the development of this new behavioral model, which they hope to use to investigate the long-term effects of early childhood neglect in people.

Arthur Simen and a team of researchers from Yale University School of Medicine, USA, tested their 'Maternal separation with early weaning' (MSEW) model in a group of 80 male mice. He said, "Childhood adversity, in the form of abuse and neglect, is prevalent throughout the world and poses a significant public health problem. Unfortunately, the underlying molecular mechanisms of the consequences of early life neglect remain largely unknown. To address this, we devised a method of maternal separation that combines several published protocols in order to increase the likelihood of observing a reliable behavioral effect while minimizing fatalities to the developing offspring."

During MSEW, mice undergo maternal separation for 4 hours per day on days 2-5 after birth, and 8 hours per day on days 6-16. They are weaned early, on day 17. The mice exposed to this treatment were found to be hyperactive and anxious, compared to control animals as determined by open field, forced swim and maze tests. However their body weight and metabolite levels were found to be unchanged revealing that nutritional deficiency was not the cause of the observed behavior.

Speaking about the results, Simen said, "MSEW is a novel paradigm with excellent face validity that allows for in depth examination of the behavioral and neurobiological effects of maternal separation."


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Elizabeth D George, Kelly A Bordner, Hani M Elwafi and Arthur A Simen. Maternal separation with early weaning: a novel mouse model of early life neglect. BMC Neuroscience, (in press) [link]

Cite This Page:

BioMed Central. "Absent mothers can cause hyperactivity and anxiety in offspring later in life, mouse study finds." ScienceDaily. ScienceDaily, 29 September 2010. <www.sciencedaily.com/releases/2010/09/100928193450.htm>.
BioMed Central. (2010, September 29). Absent mothers can cause hyperactivity and anxiety in offspring later in life, mouse study finds. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2010/09/100928193450.htm
BioMed Central. "Absent mothers can cause hyperactivity and anxiety in offspring later in life, mouse study finds." ScienceDaily. www.sciencedaily.com/releases/2010/09/100928193450.htm (accessed July 29, 2014).

Share This




More Mind & Brain News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com
University Quiz Implies Atheists Are Smarter Than Christians

University Quiz Implies Atheists Are Smarter Than Christians

Newsy (July 25, 2014) An online quiz from a required course at Ohio State is making waves for suggesting atheists are inherently smarter than Christians. Video provided by Newsy
Powered by NewsLook.com
Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins