Featured Research

from universities, journals, and other organizations

Molecular On-off Switches for Cancer and Autoimmunity Defined

Date:
October 1, 2010
Source:
Federation of American Societies for Experimental Biology
Summary:
A new report offers hope in the search for new cancer drugs. By examining the seemingly conflicting roles of how oncogenes and tumor suppressor genes handle cellular stress, scientists argue that these opposing systems could be potent cancer drug targets. In addition, their hypothesis provides new insights into what contributes to immunological disorders such as chronic inflammation and autoimmune diseases.

A new report published in the October 2010 print issue of The FASEB Journal offers a ray of hope in the search for new cancer drugs. By examining the seemingly conflicting roles of how oncogenes and tumor suppressor genes handle cellular stress, scientists from the Institute for Advanced Studies in New Jersey argue that each of these opposing systems could be potent drug targets in the effort to stop cancer. In addition, their hypothesis provides new insights into what contributes to immunological disorders such as chronic inflammation and autoimmune diseases.

Related Articles


"We hope the ideas put forward in this article will stimulate additional experiments to test these novel concepts," said Arnold Levine, Ph.D., co-author of the study from the Institute for Advanced Study in Princeton, New Jersey. "Among those experiments are the synthesis of new drugs to inhibit pathways that could change the course of a disease."

After a review of existing experimental literature, Levine and colleagues concluded that a new class of drugs could be developed to address the conflicting nature of oncogenes and tumor suppressor genes. Specifically, the research paper published in The FASEB Journal examines the roles of the p53 tumor suppressor and the oncogene, NF-kappaB. The p53 suppressor limits the consequences of stress by initiating cell death and promoting metabolic patterns in the cell. The oncogene NF-kappaB on the other hand, promotes cell division resulting in the synthesis of substrates for cell division. These two cellular responses, both of which have evolved to handle different types of stress, have adopted opposite strategies and cannot function in the same cell at the same time. As a result, Levine and colleagues speculate that drugs could be developed to take advantage of the fact that if one factor is activated, the other is rendered inactive. This could be achieved at several places in both the p53 and NF-kappaB pathways where regulatory proteins act on both with opposite functional consequences.

"Our cells use the p53 and NF-kappaB pathways to respond to cellular stress: one controls cancer, the other immunity. If they get out of balance, we're in trouble.," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Thanks to this work we can start restore the balance by means of new drugs."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. P. Ak, A. J. Levine. p53 and NF- B: different strategies for responding to stress lead to a functional antagonism. The FASEB Journal, 2010; DOI: 10.1096/fj.10-160549

Cite This Page:

Federation of American Societies for Experimental Biology. "Molecular On-off Switches for Cancer and Autoimmunity Defined." ScienceDaily. ScienceDaily, 1 October 2010. <www.sciencedaily.com/releases/2010/09/100930101545.htm>.
Federation of American Societies for Experimental Biology. (2010, October 1). Molecular On-off Switches for Cancer and Autoimmunity Defined. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2010/09/100930101545.htm
Federation of American Societies for Experimental Biology. "Molecular On-off Switches for Cancer and Autoimmunity Defined." ScienceDaily. www.sciencedaily.com/releases/2010/09/100930101545.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins