Featured Research

from universities, journals, and other organizations

DNA repair capacity identified those at high risk for non-melanoma skin cancer

Date:
October 9, 2010
Source:
American Association for Cancer Research
Summary:
DNA repair capacity measurements effectively identified individuals who were at high risk for non-melanoma skin cancer, and may be a useful method to evaluate the efficacy of preventive therapies, according to new findings.

DNA repair capacity (DRC) measurements effectively identified individuals who were at high risk for non-melanoma skin cancer, and may be a useful method to evaluate the efficacy of preventive therapies, according to study results presented at the Third AACR Conference on the Science of Cancer Health Disparities.

Related Articles


"Our study showed that persons with low DRC have three times greater likelihood of having non-melanoma skin cancer as compared to those with high DRC," said Manuel Bayona, M.D., Ph.D., professor of the Public Health Program at the Ponce School of Medicine, Puerto Rico.

DRC is a complex cellular mechanism involving more than 200 proteins that is used to repair damage to DNA within cells. Bayona explained that DNA damage can be caused by exposure to solar ultraviolet light and other types of radiation, dietary factors and aging. DRC has been linked to several types of cancer development.

The researchers conducted a case-controlled study among participants in Puerto Rico to determine whether a reduced DRC was a risk factor for non-melanoma skin cancer.

After comparing DRC levels in 477 newly-diagnosed, non-melanoma skin cancer cases and 365 controls without cancer, they found that low DRC levels were strongly associated with non-melanoma skin cancer.

Bayona and colleagues also studied key risk factors and their possible association with DRC as predictors for non-melanoma skin cancer:

  • demographics (age, gender) and family history of non-melanoma skin cancer;
  • skin, hair and eye color, and presence of freckles;
  • occupational and recreational sun exposure;
  • sunscreen use;
  • cigarette smoking;
  • vitamins, aspirin and calcium intake;
  • DRC levels; and,
  • dermatological information and other variables that could provide an estimate of non-melanoma skin cancer risk.

These findings in Puerto Rico are consistent with previous studies conducted elsewhere, according to the researchers. Additionally, participants who did not use sunblock, did not take aspirin and/or did not take multivitamin supplements regularly had increased odds of non-melanoma skin cancer.

"Doctors could use DRC levels to monitor how non-melanoma skin cancer risk decreases in individuals taking cancer preventive therapies," he said.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "DNA repair capacity identified those at high risk for non-melanoma skin cancer." ScienceDaily. ScienceDaily, 9 October 2010. <www.sciencedaily.com/releases/2010/10/101003081635.htm>.
American Association for Cancer Research. (2010, October 9). DNA repair capacity identified those at high risk for non-melanoma skin cancer. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2010/10/101003081635.htm
American Association for Cancer Research. "DNA repair capacity identified those at high risk for non-melanoma skin cancer." ScienceDaily. www.sciencedaily.com/releases/2010/10/101003081635.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
What's Different About This Latest Ebola Vaccine

What's Different About This Latest Ebola Vaccine

Newsy (Mar. 26, 2015) — A whole virus Ebola vaccine has been shown to protect monkeys exposed to the virus. Here&apos;s what&apos;s different about this vaccine. Video provided by Newsy
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins