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Personalized medicine: Identifying subsets of patients who will respond to subsequent lines of chemotherapy

Date:
October 9, 2010
Source:
European Society for Medical Oncology
Summary:
Researchers suggest it may be possible to identify subsets of metastatic breast cancer patients who are likely to respond to subsequent lines of chemotherapy.

In a study presented at the 35th Congress of the European Society for Medical Oncology (ESMO), Dr Giovanni Bernardo from Fondazione Maugeri in Pavia, Italy, presented results that suggested it may be possible to identify subsets of metastatic breast cancer patients who are likely to respond to subsequent lines of chemotherapy.

Dr Bernardo's group analysed data from 980 women treated with chemotherapy for metastatic breast cancer in their centre between 1992 and 2006.

They found that the median overall survival grew progressively smaller for each successive chemotherapy regimen the patients were given. The time to treatment failure also shortened as each new regimen was tried, from a median of 9.2 months for first-line therapy, to 7.8 and 6.4 months for the second and third-line drugs. Beyond the third line, there was no significant decrease in the medial time to treatment failure for each successive therapy.

The researchers found that only one factor they analysed affected a patient's overall survival time. That factor was the time to treatment failure for each line of chemotherapy. In other words, the more benefit one type of therapy offered, the more benefit the subsequent therapy was likely to offer.

"The implications of our analysis for clinical practice concern the possibility of deciding which patients should be offered a third- or successive chemotherapy line, considering that there are multiple treatment options available today for metastatic disease, and increasing numbers of patients ask for more options when a particular treatment fails," said Dr Bernardo.


Story Source:

The above story is based on materials provided by European Society for Medical Oncology. Note: Materials may be edited for content and length.


Cite This Page:

European Society for Medical Oncology. "Personalized medicine: Identifying subsets of patients who will respond to subsequent lines of chemotherapy." ScienceDaily. ScienceDaily, 9 October 2010. <www.sciencedaily.com/releases/2010/10/101009082823.htm>.
European Society for Medical Oncology. (2010, October 9). Personalized medicine: Identifying subsets of patients who will respond to subsequent lines of chemotherapy. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2010/10/101009082823.htm
European Society for Medical Oncology. "Personalized medicine: Identifying subsets of patients who will respond to subsequent lines of chemotherapy." ScienceDaily. www.sciencedaily.com/releases/2010/10/101009082823.htm (accessed April 18, 2014).

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