Featured Research

from universities, journals, and other organizations

New clues on how cancer spreads

Date:
October 13, 2010
Source:
University of New South Wales
Summary:
Researchers have dramatically advanced medicine's understanding of how cancer migrates, showing that cancer cells are accompanied by growth-enabling stromal cells when they travel in the bloodstream to new sites in the body.

Researchers have dramatically advanced medicine's understanding of how cancer migrates, showing that cancer cells are accompanied by growth-enabling stromal cells when they travel in the bloodstream to new sites in the body.

The discovery by University of New South Wales medical scientists challenges the prevailing belief that metastasis is the sole preserve of cancer cells. The finding has implications for all solid tumours and could lead to more effective treatments for some of our most aggressive cancers.

The researchers found that "enabling" pancreatic stellate cells (PSCs) from primary tumours have the ability to invade blood vessels to travel via the bloodstream to distant sites, where they create a hospitable environment for cancer cells to seed and grow. The findings, presented at the annual scientific meeting of the American Pancreatic Association, appear in the American Journal of Pathology.

"It's always been presumed that only cancer cells travel in metastasis. But we've shown for the first time that stellate cells also travel in tandem with the cancer cells," said the study's chief investigator and Director of UNSW's Pancreatic Research Group, Professor Minoti Apte.

"It's like the cancer brings its own luggage with it -- the stellate cells -- allowing it to settle in a new place more comfortably and more quickly."

In 2008, Professor Apte and her team identified PSCs as the cause of the fibrous growth, or stroma, prominent in pancreatic tumours. They discovered that the PSCs caused tumours to grow much faster and bigger and also resulted in more metastasis.

In the current study, PhD student Zhihong Xu used a gender mismatch approach to investigate whether these enabling cells could migrate. Female mice were injected in the pancreas with a female cancer cell line and male pancreatic stellate cells. After seven weeks, metastatic nodules in all mice showed the presence of Y chromosome-positive (male) cells.

"These could only have come from the original tumour and the male pancreatic stellate cells" Professor Apte said. "The challenge now is to stop PSCs from aiding and abetting pancreatic cancer cells -- not only in the primary tumour site but also to prevent or diminish cancer growth in distant sites."


Story Source:

The above story is based on materials provided by University of New South Wales. Note: Materials may be edited for content and length.


Journal Reference:

  1. Z. Xu, A. Vonlaufen, P. A. Phillips, E. Fiala-Beer, X. Zhang, L. Yang, A. V. Biankin, D. Goldstein, R. C. Pirola, J. S. Wilson, M. V. Apte. Role of Pancreatic Stellate Cells in Pancreatic Cancer Metastasis. American Journal Of Pathology, 2010; DOI: 10.2353/ajpath.2010.090899

Cite This Page:

University of New South Wales. "New clues on how cancer spreads." ScienceDaily. ScienceDaily, 13 October 2010. <www.sciencedaily.com/releases/2010/10/101012095225.htm>.
University of New South Wales. (2010, October 13). New clues on how cancer spreads. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2010/10/101012095225.htm
University of New South Wales. "New clues on how cancer spreads." ScienceDaily. www.sciencedaily.com/releases/2010/10/101012095225.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins