Featured Research

from universities, journals, and other organizations

New clues on how cancer spreads

Date:
October 13, 2010
Source:
University of New South Wales
Summary:
Researchers have dramatically advanced medicine's understanding of how cancer migrates, showing that cancer cells are accompanied by growth-enabling stromal cells when they travel in the bloodstream to new sites in the body.

Researchers have dramatically advanced medicine's understanding of how cancer migrates, showing that cancer cells are accompanied by growth-enabling stromal cells when they travel in the bloodstream to new sites in the body.

The discovery by University of New South Wales medical scientists challenges the prevailing belief that metastasis is the sole preserve of cancer cells. The finding has implications for all solid tumours and could lead to more effective treatments for some of our most aggressive cancers.

The researchers found that "enabling" pancreatic stellate cells (PSCs) from primary tumours have the ability to invade blood vessels to travel via the bloodstream to distant sites, where they create a hospitable environment for cancer cells to seed and grow. The findings, presented at the annual scientific meeting of the American Pancreatic Association, appear in the American Journal of Pathology.

"It's always been presumed that only cancer cells travel in metastasis. But we've shown for the first time that stellate cells also travel in tandem with the cancer cells," said the study's chief investigator and Director of UNSW's Pancreatic Research Group, Professor Minoti Apte.

"It's like the cancer brings its own luggage with it -- the stellate cells -- allowing it to settle in a new place more comfortably and more quickly."

In 2008, Professor Apte and her team identified PSCs as the cause of the fibrous growth, or stroma, prominent in pancreatic tumours. They discovered that the PSCs caused tumours to grow much faster and bigger and also resulted in more metastasis.

In the current study, PhD student Zhihong Xu used a gender mismatch approach to investigate whether these enabling cells could migrate. Female mice were injected in the pancreas with a female cancer cell line and male pancreatic stellate cells. After seven weeks, metastatic nodules in all mice showed the presence of Y chromosome-positive (male) cells.

"These could only have come from the original tumour and the male pancreatic stellate cells" Professor Apte said. "The challenge now is to stop PSCs from aiding and abetting pancreatic cancer cells -- not only in the primary tumour site but also to prevent or diminish cancer growth in distant sites."


Story Source:

The above story is based on materials provided by University of New South Wales. Note: Materials may be edited for content and length.


Journal Reference:

  1. Z. Xu, A. Vonlaufen, P. A. Phillips, E. Fiala-Beer, X. Zhang, L. Yang, A. V. Biankin, D. Goldstein, R. C. Pirola, J. S. Wilson, M. V. Apte. Role of Pancreatic Stellate Cells in Pancreatic Cancer Metastasis. American Journal Of Pathology, 2010; DOI: 10.2353/ajpath.2010.090899

Cite This Page:

University of New South Wales. "New clues on how cancer spreads." ScienceDaily. ScienceDaily, 13 October 2010. <www.sciencedaily.com/releases/2010/10/101012095225.htm>.
University of New South Wales. (2010, October 13). New clues on how cancer spreads. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2010/10/101012095225.htm
University of New South Wales. "New clues on how cancer spreads." ScienceDaily. www.sciencedaily.com/releases/2010/10/101012095225.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com
Carpenter's Injury Leads To Hundreds Of 3-D-Printed Hands

Carpenter's Injury Leads To Hundreds Of 3-D-Printed Hands

Newsy (Apr. 14, 2014) Richard van As lost all fingers on his right hand in a woodworking accident. Now, he's used the incident to create a prosthetic to help hundreds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins