Featured Research

from universities, journals, and other organizations

Afatinib benefits lung cancer patients whose cancer progressed after treatment with EGFR inhibitors, trial shows

Date:
October 12, 2010
Source:
European Society for Medical Oncology
Summary:
Lung cancer patients who have already been treated with the EGFR inhibitors erlotinib or gefitinib seem to gain further benefits in terms of progression-free survival and tumor shrinkage when treated with the new drug afatinib, the results of a Phase IIb/III trial show.

Lung cancer patients who have already been treated with the EGFR inhibitors erlotinib or gefitinib seem to gain further benefits in terms of progression-free survival and tumor shrinkage when treated with the new drug afatinib, the results of a Phase IIb/III trial show.

At the 35th Congress of the European Society for Medical Oncology (ESMO) in Milan, Italy, Dr Vincent Miller from Memorial Sloan-Kettering Cancer Center in New York, USA, reported findings from the LUX-Lung 1 trial of afatinib in 585 patients with lung adenocarcinoma whose cancer had progressed after chemotherapy and erlotinib or gefitinib.

The participants were randomly assigned to either best supportive care plus a placebo, or supportive care plus afatinib, which is an irreversible inhibitor of two cancer-associated cell surface molecules --epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2).

While the results showed no significant difference in overall survival between the two groups, patients who were given afatinib saw disease progression delayed and were more likely to experience tumor shrinkage, Dr Miller said.

Median overall survival was 10.78 months for patients who received supportive care plus afatinib, compared to 11.96 months for those receiving supportive care plus placebo. "The median overall survival for both arms was expected to be approximately five months," Dr Miller said. "The fact that it was nearly one year was unexpected."

Median progression-free survival was 3.3 months for patients administered afatinib, compared to 1.1 month in the placebo group. The disease control rate after 8 weeks of therapy was 58% in the afatinib arm, and 19% for the placebo arm. The investigator analysis saw an overall response rate of 11% in afatinib patients, compared to 0.5% for those receiving placebo plus best supportive care.

"Our study showed that adding afatinib to best supportive care improved progression free but not overall survival as compared to placebo and best supportive care in patients with advanced non-small cell lung cancer who previously received chemotherapy and either gefitinib or erlotinib," Dr Miller said.

Although the trial did not achieve its primary endpoint of extending life, this does not diminish the potential value of this drug in treating patients with this most lethal cancer killer, Dr Miller said.

"The fact that afatinib induced objective regressions in a population with no or limited treatment options, delayed progression of cancer and associated with some improvement in cancer-related symptoms cannot be minimized," said Dr Miller.

"The LUX-lung 1 randomized phase III trial demonstrates that afatinib (BIBW2992) is a very active compound in NSCLC," commented Professor Jean-Charles Soria from Institut Gustave Roussy, Paris, France.

"The lack of survival benefit may be related to the likely high enrichment of the trial population by EGFR mutated patients with outstanding median survival times of around 11 months in the 3rd/4th line setting," Prof Soria added. Such survivals are unprecedented in NSCLC and simply highlight the intrinsic good prognosis of EGFR-mutated NSCLC patients.


Story Source:

The above story is based on materials provided by European Society for Medical Oncology. Note: Materials may be edited for content and length.


Cite This Page:

European Society for Medical Oncology. "Afatinib benefits lung cancer patients whose cancer progressed after treatment with EGFR inhibitors, trial shows." ScienceDaily. ScienceDaily, 12 October 2010. <www.sciencedaily.com/releases/2010/10/101012114218.htm>.
European Society for Medical Oncology. (2010, October 12). Afatinib benefits lung cancer patients whose cancer progressed after treatment with EGFR inhibitors, trial shows. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2010/10/101012114218.htm
European Society for Medical Oncology. "Afatinib benefits lung cancer patients whose cancer progressed after treatment with EGFR inhibitors, trial shows." ScienceDaily. www.sciencedaily.com/releases/2010/10/101012114218.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins