Featured Research

from universities, journals, and other organizations

Diabetes gene linked to degeneration of enzyme involved in Alzheimer's disease onset and progression

Date:
October 13, 2010
Source:
The Mount Sinai Hospital / Mount Sinai School of Medicine
Summary:
Researchers have found that a gene associated with the onset of type 2 diabetes also is found at lower-than-normal levels in people with Alzheimer's disease.

Mount Sinai School of Medicine researchers have found that a gene associated with the onset of Type 2 diabetes also is found at lower-than-normal levels in people with Alzheimer's disease. The research, led by Giulio Maria Pasinetti, MD, PhD, The Saunder Family Professor in Neurology, and Professor of Psychiatry and Geriatrics and Adult Development at Mount Sinai School of Medicine, was published this month in Aging Cell.

Related Articles


The new study provides insight into a potential mechanism that might explain the relationship between Type 2 diabetes and the onset and progression of Alzheimer's disease. Recent evidence indicates that healthy elderly subjects affected by Type 2 diabetes are twice as likely to develop Alzheimer's disease, but researchers have been unable to explain how.

"The relationship between Type 2 diabetes and Alzheimer's disease has been elusive," said Dr. Pasinetti. "This new evidence is of extreme interest, especially since approximately 60 percent of Alzheimer's disease cases have at least one serious medical condition primarily associated with Type 2 diabetes."

Using mice that were genetically engineered to have Alzheimer's disease comparable to that seen in humans, Dr. Pasinetti and colleagues found that a gene known as proliferator-activated receptor coactivator 1 (PGC-1), a key regulator of glucose currently investigated as a potential therapeutic target for Type 2 diabetes, is decreased in Alzheimer's disease. The team reports that this decrease might be causally linked to promotion of Alzheimer's disease. They found that PGC-1 promotes degradation of a specific enzyme known as beta-secretase (BACE). ACE is directly involved in the processing and eventually generation of β-amyloid, an abnormal protein highly linked to Alzheimer's disease and brain degeneration.

"Our research is the first to find that PGC-1 is a common denominator between Type 2 diabetes and Alzheimer's disease," said Dr. Pasinetti. "This discovery will have significant implications for the more than five million Americans affected by Alzheimer's disease, a number that is expected to skyrocket in the next three decades as the population ages. We look forward to continuing to research this discovery and translate it into the development of novel approaches for disease prevention and treatment."

Dr. Pasinetti and his colleagues are optimistic that if they find that PGC-1 can be manipulated pharmacologically to prevent BACE accumulation in the brain, these studies will provide important insights for the formulation of novel treatments and possible preventative strategies in Alzheimer's disease.


Story Source:

The above story is based on materials provided by The Mount Sinai Hospital / Mount Sinai School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bing Gong, Fei Chen, Yong Pan, Isabel Arrieta-Cruz, Yukiko Yoshida, Vahram Haroutunian, Giulio Maria Pasinetti. SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function. Aging Cell, 2010; DOI: 10.1111/j.1474-9726.2010.00632.x

Cite This Page:

The Mount Sinai Hospital / Mount Sinai School of Medicine. "Diabetes gene linked to degeneration of enzyme involved in Alzheimer's disease onset and progression." ScienceDaily. ScienceDaily, 13 October 2010. <www.sciencedaily.com/releases/2010/10/101012151244.htm>.
The Mount Sinai Hospital / Mount Sinai School of Medicine. (2010, October 13). Diabetes gene linked to degeneration of enzyme involved in Alzheimer's disease onset and progression. ScienceDaily. Retrieved February 28, 2015 from www.sciencedaily.com/releases/2010/10/101012151244.htm
The Mount Sinai Hospital / Mount Sinai School of Medicine. "Diabetes gene linked to degeneration of enzyme involved in Alzheimer's disease onset and progression." ScienceDaily. www.sciencedaily.com/releases/2010/10/101012151244.htm (accessed February 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, February 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Reuters - Innovations Video Online (Feb. 27, 2015) A dongle that plugs into a Smartphone mimics a lab-based blood test for HIV and syphilis and can detect the diseases in 15 minutes, say researchers. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Doctor Says Head Transplants Possible Within Two Years

Doctor Says Head Transplants Possible Within Two Years

Buzz60 (Feb. 27, 2015) An Italian doctor is saying he could stick someone&apos;s head onto someone else&apos;s body. Patrick Jones (@Patrick_E_Jones) reports. Video provided by Buzz60
Powered by NewsLook.com
How Your Dentist Could Help Screen You For Diabetes

How Your Dentist Could Help Screen You For Diabetes

Newsy (Feb. 27, 2015) A new study from researchers at New York University suggests dentists could soon use blood samples taken from patients&apos; mouths to test for diabetes. Video provided by Newsy
Powered by NewsLook.com
The Best Tips to Makeover Your Health

The Best Tips to Makeover Your Health

Buzz60 (Feb. 27, 2015) If you&apos;re looking to boost your health this season, there are a few quick and easy steps to prompt you for success. Krystin Goodwin (@Krystingoodwin) has the best tips to give your health a makeover this spring! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins