Featured Research

from universities, journals, and other organizations

New research helps clinicians predict treatment outcomes for children with obsessive compulsive disorder

Date:
October 15, 2010
Source:
Lifespan
Summary:
New research may help clinicians better predict how a child with obsessive compulsive disorder (OCD) will respond to some of the most commonly used treatment approaches.

New research from the Bradley Hasbro Children's Research Center may help clinicians better predict how a child with obsessive compulsive disorder (OCD) will respond to some of the most commonly used treatment approaches. The findings, published in the October issue of the Journal of the American Academy of Child and Adolescent Psychiatry, could help guide important clinical decisions about the best intervention for children with this often debilitating anxiety disorder.

Related Articles


"Until now, there has been little information about which OCD treatment to recommend to particular pediatric patients," said lead author Abbe Garcia, PhD, director of the Bradley Hasbro Children's Research Center (BHCRC) Pediatric Anxiety Research Clinic. "Our study identified some characteristics of children with OCD that could help us predict which patients are most likely to benefit from particular treatments, similar to a personalized medicine approach."

OCD is an anxiety disorder characterized by recurrent, unwanted thoughts (obsessions) and/or repetitive behaviors (compulsions). The symptoms reported by children are similar to those seen among adults with OCD. According to the American Academy of Child and Adolescent Psychiatry, as many as 1 in 200 children and adolescents struggle with OCD.

Researchers focused on outcomes of the three most commonly used treatment approaches for pediatric OCD: a form of psychotherapy known as cognitive behavioral therapy (CBT) that teaches children to face their fears; sertraline, a selective serotonin reuptake inhibitor (SSRI); and a combination of the two.

They found that children with less severe OCD symptoms, fewer co-existing behavior problems and children whose symptoms cause less impairment in their everyday lives showed greater improvement across all of the treatments. Also, children who were better able to recognize their symptoms as irrational fared better, regardless of the treatment course. In addition, patients from families that were less accommodating of the child's OCD symptoms were also more successful in all treatments.

The study also revealed an intriguing connection between OCD treatment outcome and family history: patients with a parent and/or sibling with OCD did six times worse in CBT than their peers without a family history of OCD. Garcia says this could be due to the nature of CBT, which requires more family support and at-home involvement than medication compliance, something that could be more difficult when a parent or other sibling is also dealing with OCD.

"Based on our findings, cognitive behavioral therapy with or without a concomitant medication is the treatment of choice for children and teens with OCD who do not have a parent or sibling who is also affected," said Garcia. "For those children with a family history, cognitive behavioral therapy in combination with a medication is probably the most effective treatment approach."

The study included 112 children between the ages of 7 and 17 with a primary diagnosis of OCD but who were not currently being treated. The group included roughly even amounts of males and females as well as younger and older children. All participants were randomly assigned to one of four treatment approaches: CBT and setraline; setraline; CBT only; and a placebo. Researchers analyzed how children responded after 12 weeks of treatment using the Children's Yale-Brown Obsessive Compulsive Scale, a clinical tool used to measure a patient's level of impairment and distress.

Garcia is also on the faculty of The Warren Alpert Medical School of Brown University. Other researchers involved in the study, which was funded by the National Institute of Mental Health, included Jennifer Freeman, PhD, also of the Bradley Hasbro Children's Research Center and Alpert Medical School; Jeffrey J. Saptya, PhD, Phoebe S. Moore, PhD, and John S. March, MD, MPH, from Duke University Medical Center; and Martin E. Franklin, PhD, and Edna B. Foa, PhD, from the University of Pennsylvania School of Medicine.


Story Source:

The above story is based on materials provided by Lifespan. Note: Materials may be edited for content and length.


Journal Reference:

  1. Abbe Marrs Garcia, Jeffrey J. Sapyta, Phoebe S. Moore, Jennifer B. Freeman, Martin E. Franklin, John S. March, Edna B. Foa. Predictors and Moderators of Treatment Outcome in the Pediatric Obsessive Compulsive Treatment Study (POTS I). Journal of the American Academy of Child and Adolescent Psychiatry, 2010; DOI: 10.1016/j.jaac.2010.06.013

Cite This Page:

Lifespan. "New research helps clinicians predict treatment outcomes for children with obsessive compulsive disorder." ScienceDaily. ScienceDaily, 15 October 2010. <www.sciencedaily.com/releases/2010/10/101014111331.htm>.
Lifespan. (2010, October 15). New research helps clinicians predict treatment outcomes for children with obsessive compulsive disorder. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2010/10/101014111331.htm
Lifespan. "New research helps clinicians predict treatment outcomes for children with obsessive compulsive disorder." ScienceDaily. www.sciencedaily.com/releases/2010/10/101014111331.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins