Featured Research

from universities, journals, and other organizations

Protein preserves delicate balance between immune response and host

Date:
November 7, 2010
Source:
Cell Press
Summary:
The immune system possesses a highly effective arsenal of cellular and chemical weapons that stand ready to defend us from harmful pathogens. However, these same mechanisms that are designed for protection can sometimes wreak havoc on our own body. Now, new research provides insight into the mechanisms that regulate natural checks and balances that optimize the immune response against potential threats while preserving host tissues.

White blood cells called neutrophils are part of the body's first line of defense against bacterial infection. Neutrophils are recruited from the bloodstream to infected tissues where they release powerful chemicals that kill bacteria and amplify the immune response. These cells function as first responders at the scene of infection and often have a short life span. As a result, new neutrophils are produced continuously from stem cells in the bone marrow. Previous research has suggested that regulation of neutrophil production is a complex and carefully controlled process.

"We know that the protein CEACAM1 is involved in the regulation of white blood cells, but its specific role in neutrophil-dependent host immune responses has not been investigated," explains senior study author, Dr. John E. Shively from the Beckman Research Institute of City of Hope in Duarte, California. "We were interested in determining what would happen to neutrophil-mediated immunity in mice that did not express CEACAM1." Dr. Shively and coauthor Dr. Hao Pan found that mice lacking CEACAM1 had an excess number of neutrophils and that CEACAM1 inhibited a specific signaling pathway that is required for white blood cell proliferation.

Interestingly, the excess neutrophils did not provide any additional protection from bacterial infection. In contrast, after infection with Listeria, mice without CEACAM1 died dramatically faster than control mice. The researchers went on to show that the mice lacking CEACAM1 exhibited improved bacterial clearance, but that this was accompanied by severe tissue damage to the liver. The authors concluded that the combination of high levels of neutrophil-secreted chemicals damaged the liver and induced accelerated mortality in Listeria-infected mice lacking CEACAM1. "The insights from our work highlight the importance of natural mechanisms that restrain white blood cell proliferation and may have clinical implications in treating infectious and auto-inflammatory disorders," says Dr. Shively


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "Protein preserves delicate balance between immune response and host." ScienceDaily. ScienceDaily, 7 November 2010. <www.sciencedaily.com/releases/2010/10/101028121104.htm>.
Cell Press. (2010, November 7). Protein preserves delicate balance between immune response and host. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2010/10/101028121104.htm
Cell Press. "Protein preserves delicate balance between immune response and host." ScienceDaily. www.sciencedaily.com/releases/2010/10/101028121104.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Reasons Why Teen Birth Rates Are At An All-Time Low

Reasons Why Teen Birth Rates Are At An All-Time Low

Newsy (Aug. 20, 2014) A CDC report says birth rates among teenagers have been declining for decades, reaching a new low in 2013. We look at several popular explanations. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins