Featured Research

from universities, journals, and other organizations

Protein preserves delicate balance between immune response and host

Date:
November 7, 2010
Source:
Cell Press
Summary:
The immune system possesses a highly effective arsenal of cellular and chemical weapons that stand ready to defend us from harmful pathogens. However, these same mechanisms that are designed for protection can sometimes wreak havoc on our own body. Now, new research provides insight into the mechanisms that regulate natural checks and balances that optimize the immune response against potential threats while preserving host tissues.

White blood cells called neutrophils are part of the body's first line of defense against bacterial infection. Neutrophils are recruited from the bloodstream to infected tissues where they release powerful chemicals that kill bacteria and amplify the immune response. These cells function as first responders at the scene of infection and often have a short life span. As a result, new neutrophils are produced continuously from stem cells in the bone marrow. Previous research has suggested that regulation of neutrophil production is a complex and carefully controlled process.

"We know that the protein CEACAM1 is involved in the regulation of white blood cells, but its specific role in neutrophil-dependent host immune responses has not been investigated," explains senior study author, Dr. John E. Shively from the Beckman Research Institute of City of Hope in Duarte, California. "We were interested in determining what would happen to neutrophil-mediated immunity in mice that did not express CEACAM1." Dr. Shively and coauthor Dr. Hao Pan found that mice lacking CEACAM1 had an excess number of neutrophils and that CEACAM1 inhibited a specific signaling pathway that is required for white blood cell proliferation.

Interestingly, the excess neutrophils did not provide any additional protection from bacterial infection. In contrast, after infection with Listeria, mice without CEACAM1 died dramatically faster than control mice. The researchers went on to show that the mice lacking CEACAM1 exhibited improved bacterial clearance, but that this was accompanied by severe tissue damage to the liver. The authors concluded that the combination of high levels of neutrophil-secreted chemicals damaged the liver and induced accelerated mortality in Listeria-infected mice lacking CEACAM1. "The insights from our work highlight the importance of natural mechanisms that restrain white blood cell proliferation and may have clinical implications in treating infectious and auto-inflammatory disorders," says Dr. Shively


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "Protein preserves delicate balance between immune response and host." ScienceDaily. ScienceDaily, 7 November 2010. <www.sciencedaily.com/releases/2010/10/101028121104.htm>.
Cell Press. (2010, November 7). Protein preserves delicate balance between immune response and host. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2010/10/101028121104.htm
Cell Press. "Protein preserves delicate balance between immune response and host." ScienceDaily. www.sciencedaily.com/releases/2010/10/101028121104.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins