Featured Research

from universities, journals, and other organizations

Breast density, no lobular involution increase breast cancer risk, study finds

Date:
October 31, 2010
Source:
Journal of the National Cancer Institute
Summary:
Women with dense breasts and no lobular involution were at a higher risk for developing breast cancer than those with non-dense breasts and complete involution, according to a new study.

Women with dense breasts and no lobular involution were at a higher risk for developing breast cancer than those with non-dense breasts and complete involution, according to a study published online in The Journal of the National Cancer Institute.

Related Articles


Apart from age, family history, and age at menarche, two additional factors associated with breast cancer risk include mammographic breast density and extent of lobular involution. Lobular involution is the physiological atrophy of the breast epithelium and is known to increase with increasing age.

To determine whether these two factors are independently associated with breast cancer risk, Karthik Ghosh, M.D., of the Mayo Clinic, and colleagues investigated the factors' association with breast cancer risk in a cohort of 2666 women with benign breast disease, followed for a mean of 13.3 years; 172 (6.5%) women subsequently developed breast cancer.

The researchers took their cohort from the larger Mayo Breast Disease cohort, which included 9376 women between the ages of 18 and 85, with no history of breast cancer, who were diagnosed with benign breast disease between 1967 and the end of 1991.

The researchers found that breast density and extent of lobular involution were independent risk factors for breast cancer, and that combined, they pose an even greater risk. The authors write: "Our findings also reveal that having a combination of dense breasts and no lobular involution was associated with higher breast cancer risk than having non-dense or fatty breasts and complete involution."

The researchers write that one of the study's strengths is that it was conducted in a large, well-organized cohort of women; however, limitations include the fact that the study population was predominantly white and representative of the upper Midwest, pointing to the need to conduct research in diverse populations.

In an accompanying editorial, Gretchen L. Gierach, Ph.D., of the National Cancer Institute, and colleagues, describe lobular involution and mammographic breast density as factors that "hold promise for improving risk prediction, particularly because they reflect the cumulative interplay of numerous genetic and environmental breast cancer risk factors over time."

Future studies, they write, should include larger numbers of patients from diverse racial and ethnic backgrounds and aim to understand the relationship between involution and epidemiological risk factors such as body mass index. Furthermore, since neither lobular involution nor mammographic breast density are static processes, evaluating changes over time may improve their predictive value.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. K. Ghosh, C. M. Vachon, V. S. Pankratz, R. A. Vierkant, S. S. Anderson, K. R. Brandt, D. W. Visscher, C. Reynolds, M. H. Frost, L. C. Hartmann. Independent Association of Lobular Involution and Mammographic Breast Density With Breast Cancer Risk. JNCI Journal of the National Cancer Institute, 2010; DOI: 10.1093/jnci/djq414

Cite This Page:

Journal of the National Cancer Institute. "Breast density, no lobular involution increase breast cancer risk, study finds." ScienceDaily. ScienceDaily, 31 October 2010. <www.sciencedaily.com/releases/2010/10/101029183754.htm>.
Journal of the National Cancer Institute. (2010, October 31). Breast density, no lobular involution increase breast cancer risk, study finds. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2010/10/101029183754.htm
Journal of the National Cancer Institute. "Breast density, no lobular involution increase breast cancer risk, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/10/101029183754.htm (accessed March 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Ways To Celebrate National Nutrition Month

The Best Ways To Celebrate National Nutrition Month

Buzz60 (Mar. 2, 2015) Just when your New Year&apos;s Resolution is losing steam, March comes with fresh inspiration. TC Newman (@PurpleTCNewman) has some tips to incorporate into your lifestyle during National Nutrition Month. Video provided by Buzz60
Powered by NewsLook.com
WHO: 1.1 Billion At Risk Of Hearing Loss, Will They Listen?

WHO: 1.1 Billion At Risk Of Hearing Loss, Will They Listen?

Newsy (Mar. 2, 2015) According to the World Health Organization, 1.1 billion young people are at risk of hearing loss. Can this staggering number change things? Video provided by Newsy
Powered by NewsLook.com
Rehab Robot Helps Restore Damaged Muscles and Nerves

Rehab Robot Helps Restore Damaged Muscles and Nerves

Reuters - Innovations Video Online (Mar. 1, 2015) A rehabilitation robot prototype to help restore deteriorated nerves and muscles using electromyography and computer games. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com
How Facebook Use Can Lead To Depression

How Facebook Use Can Lead To Depression

Newsy (Mar. 1, 2015) Margaret Duffy of the University of Missouri talks about her study on the social network and the envy and depression that Facebook use can cause. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins