Featured Research

from universities, journals, and other organizations

Colorectal cancer survival advantage in MUTYH-associated polyposis

Date:
November 2, 2010
Source:
Journal of the National Cancer Institute
Summary:
Survival for colorectal cancer patients with MUTYH-associated polyposis was statistically significantly better than for patients with colorectal cancer from the general population, according to a recent study.

Survival for colorectal cancer patients with MUTYH-associated polyposis was statistically significantly better than for patients with colorectal cancer from the general population, according to a recent study published online November 2 in The Journal of the National Cancer Institute.

People who inherit a mutation in the MUTYH gene have nearly a 100% risk for developing colon cancer at some point in their lifetimes. But it is unknown whether specific histological and molecular genetic features of cancer associated with this genotype influence tumor behavior and survival.

To determine whether patients with MUTYH-associated polyposis colorectal cancer had different survival rates than control colorectal cancer patients, Maartje Nielsen, M.D., of the Leiden University Medical Center, and colleagues, conducted a multicenter cohort study in Europe that included 147 patients with MUTYH-associated polyposis colorectal cancer and 272 population-based control patients with colorectal cancer. Control and study group patients were matched for country, stage, age and year at diagnosis, and cancer subsite.

The researchers found that survival of patients with MUTYH-associated polyposis colorectal cancer was statistically significantly better than for control patients with colorectal cancer. Their five-year survival rate was 78% compared with 63% for the control group. Survival benefit was higher among patients with stage I and II disease than for those with stage III and IV disease.

The researchers offer a speculation about the better survival rate among the patients with MUTYH-associated polyposis colorectal cancer, compared with the control patients: "A compromised base excision repair system could render MUTYH-associated polyposis colorectal cancer more immunogenic than sporadic colorectal cancers, which are characterized predominantly by chromosomal instability."

In an accompanying editorial, Henry T. Lynch, MD, and Stephen J. Lanspa, MD, of Creighton University, hypothesize that the cancer-causing mutations in MUTYH, as well as in the mismatch repair genes predisposing to Lynch syndrome, are the causal factors for their respective survival advantages. Furthermore, they write, "the ultimate understanding of the pathogenetic pathways elicited by these respective mutations may serve as models for studying both survival and increased virulence of hereditary and sporadic colorectal cancers."


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Maartje Nielsen, Liza N. van Steenbergen, Natalie Jones, Stefanie Vogt, Hans F. A. Vasen, Hans Morreau, Stefan Aretz, Julian R. Sampson, Olaf M. Dekkers, Maryska L. G. Janssen-Heijnen, Frederik J. Hes. Survival of MUTYH-Associated Polyposis Patients With Colorectal Cancer and Matched Control Colorectal Cancer Patients. The Journal of the National Cancer Institute, 2010; DOI: 10.1093/jnci/djq370

Cite This Page:

Journal of the National Cancer Institute. "Colorectal cancer survival advantage in MUTYH-associated polyposis." ScienceDaily. ScienceDaily, 2 November 2010. <www.sciencedaily.com/releases/2010/11/101102163952.htm>.
Journal of the National Cancer Institute. (2010, November 2). Colorectal cancer survival advantage in MUTYH-associated polyposis. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2010/11/101102163952.htm
Journal of the National Cancer Institute. "Colorectal cancer survival advantage in MUTYH-associated polyposis." ScienceDaily. www.sciencedaily.com/releases/2010/11/101102163952.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins