A study funded by the Motor Neurone Disease (MND) Association, in collaboration with the Medical Research Council (MRC), has identified a common signature of nerve damage in the brains of MND patients.
The study's findings were published November 2, 2010 in the journal Neurology. These are the first results to be published from the ongoing Oxford Study for Biomarkers in MND/ALS (BioMOx).
First steps to developing a test for MND
MND research is being held back by the lack of an early diagnostic test and predictable markers of the progression of the disease -- biomarkers. Patients still wait too long for a certain diagnosis of MND and clinical trials are hampered by lengthy study times and variability of the disease between people living with MND. If MND biomarkers can be identified then they could dramatically improve the speed and accuracy with which MND can be diagnosed, and how future treatments are assessed.
This study used an advanced magnetic resonance imaging (MRI) technique, to look for areas of the brain that are universally damaged in patients with MND as compared to healthy controls. From this, Dr Martin Turner and colleagues at the University of Oxford found a unique similarity of nerve damage in a region of the brain that connects the motor neurons to the brain as well as damage to a region that acts as a connection between the left and right sides of the brain known as the 'corpus callosum'.
Talking about the study findings, Dr Martin Turner says: "The finding of a common pattern of nerve pathway damage in a varied group of MND patients holds the promise of a much needed biomarker.
"This study confirms the ability of advanced MRI techniques to sensitively detect nerve damage in a wide range of people living with MND. It builds on a decade of international work, and shows that MRI is now a frontrunner in the quest to generate biomarkers of disease activity in MND."
Dr Brian Dickie, director of research development at the MND Association, adds: "MRI scanning provides an exciting 'window on the brain', allowing researchers to link the changes occurring in the central nervous system with the 'real world' symptoms of MND. Understanding these changing events is going to be central to the development of future treatments."
About the BioMOx study
The BioMOx study aims to develop a biomarker for MND by following changes in the brain, in the blood and in spinal cord fluid of people living with MND, every six months. People living with MND have made, and continue to make, a significant contribution in giving their time and effort to make this research project possible.
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