Featured Research

from universities, journals, and other organizations

Protein with cardioprotective capabilities during heart attack discovered

Date:
November 17, 2010
Source:
University of Cincinnati Academic Health Center
Summary:
Researchers have discovered a new protein that could be cardioprotective during heart attack, potentially leading to more targeted treatments for patients at risk.

University of Cincinnati researchers have discovered a new protein that could be cardioprotective during heart attack, potentially leading to more targeted treatments for patients at risk.

These findings are being presented at the American Heart Association's (AHA) Scientific Sessions in Chicago Nov. 16.

Researchers in the department of pharmacology and cell biophysics, led by Wen Zhao, PhD, and Chi Keung Lam, a PhD student, under the direction of Litsa Kranias, PhD, AHA distinguished scientist and chair of the department, found that HAX-1, an anti-cell death protein, plays an important role in protecting cardiac cells and muscle during ischemia-reperfusion injury, or damage to tissue caused by blood restriction.

"Multiple cell death pathways are activated during heart attack, resulting in cell death and reduced cardiac function," Lam says. "HAX-1 has been reported to have involvement in different cell death mechanisms.

"We found that HAX-1 protein levels were reduced in hearts after ischemia-reperfusion injury."

In this study, researchers created animal models with cardiac-specific, over-produced HAX-1 by twofold and then experimentally induced heart attack.

"The hearts of these animal models showed improved contractile performance after heart attack-related injury and decreased cell death," Zhao says. "The protective effect was associated with decreased activities of caspases three and nine. Caspases are a family of proteins that are one of the main executors of the cell-death process."

Zhao also found that mitochondria isolated from HAX-1 in the hearts of these models were resistant to swelling and to permeability transition (MPT), or decrease in the permeability of the mitochondrial membranes by calcium.

Lam adds that hearts of these models also had reduced stress response in the endoplasmic reticulum (ER), or the interconnected network within cells that synthesizes proteins, following injury.

"These findings suggest the unique cardioprotective potential of HAX-1 in ischemia-reperfusion injury," Zhao says. "The discoveries could lead to targeted treatments at the cellular level for patients who are at risk for heart attack and prevent cell and tissue death from ever occurring."

This study was funded by an AHA pre-doctoral fellowship grant, the National Institutes of Health and the Leducq Foundation.


Story Source:

The above story is based on materials provided by University of Cincinnati Academic Health Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Cincinnati Academic Health Center. "Protein with cardioprotective capabilities during heart attack discovered." ScienceDaily. ScienceDaily, 17 November 2010. <www.sciencedaily.com/releases/2010/11/101116103624.htm>.
University of Cincinnati Academic Health Center. (2010, November 17). Protein with cardioprotective capabilities during heart attack discovered. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2010/11/101116103624.htm
University of Cincinnati Academic Health Center. "Protein with cardioprotective capabilities during heart attack discovered." ScienceDaily. www.sciencedaily.com/releases/2010/11/101116103624.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins