Featured Research

from universities, journals, and other organizations

Teenage amphetamine abuse affects adult brain cell function

Date:
November 16, 2010
Source:
Society for Neuroscience
Summary:
Amphetamine abuse during adolescence permanently changes brain cells, according to new animal research. The study shows drug exposure during adolescence, but not young adulthood, altered electrical properties of brain cells in the cortex.

Amphetamine abuse during adolescence permanently changes brain cells, according to new animal research. The study shows drug exposure during adolescence, but not young adulthood, altered electrical properties of brain cells in the cortex.

The findings were presented at Neuroscience 2010, the annual meeting of the Society for Neuroscience, held in San Diego.

Many children and teens with attention deficit hyperactivity disorder benefit from taking amphetamines, such as Adderallฎ, when closely supervised by parents and physicians. However, these drugs are also highly abused by healthy individuals, particularly adolescents between the ages of 12 and 17, a period when the brain continues to develop and mature.

To test the effects of amphetamine abuse on adult brain cell function, researchers at the University of Illinois, Urbana- Champaign repeatedly treated adolescent and young adult rats with the drug. When the rats reached adulthood, the researchers examined brain cells in the prefrontal cortex, a region important in memory, decision-making, and impulse control.

Brain cells from rats exposed to amphetamine abuse in adolescence, but not young adulthood, showed abnormal responses to electrical stimulation and insensitivity to the brain chemical dopamine. Because brain cells communicate using both electrical and chemical signals, these findings may indicate drug-induced disruptions in brain function.

Previous research showed deficits in working memory in adult rats exposed to amphetamines in adolescence. "Our new findings reveal that this change in cognitive behavior may be due in part to long-lasting changes in the function of neurons in the prefrontal cortex," said the study's senior author, Joshua Gulley, PhD. "We hypothesize that this is due to amphetamine disrupting the normal processes of brain development," he said.

Research was supported by the National Eye Institute.


Story Source:

The above story is based on materials provided by Society for Neuroscience. Note: Materials may be edited for content and length.


Cite This Page:

Society for Neuroscience. "Teenage amphetamine abuse affects adult brain cell function." ScienceDaily. ScienceDaily, 16 November 2010. <www.sciencedaily.com/releases/2010/11/101116104311.htm>.
Society for Neuroscience. (2010, November 16). Teenage amphetamine abuse affects adult brain cell function. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2010/11/101116104311.htm
Society for Neuroscience. "Teenage amphetamine abuse affects adult brain cell function." ScienceDaily. www.sciencedaily.com/releases/2010/11/101116104311.htm (accessed April 20, 2014).

Share This



More Mind & Brain News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Study On Artists' Brain Shows They're 'Structurally Unique'

Study On Artists' Brain Shows They're 'Structurally Unique'

Newsy (Apr. 17, 2014) — The brains of artists aren't really left-brain or right-brain, but rather have extra neural matter in visual and motor control areas. Video provided by Newsy
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) — A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Are School Dress Codes Too Strict?

Are School Dress Codes Too Strict?

AP (Apr. 16, 2014) — Pushing the limits on style and self-expression is a rite of passage for teens and even younger kids. How far should schools go with their dress codes? The courts have sided with schools in an era when school safety is paramount. (April 16) Video provided by AP
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) — A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins