Featured Research

from universities, journals, and other organizations

Brain tissue loss in people with Alzheimer’s disease and mild cognitive impairment

Date:
November 29, 2010
Source:
Society for Neuroscience
Summary:
People with Alzheimer's disease exhibit striking structural changes in the caudate nucleus, a brain structure typically associated with movement disorders such as Parkinson's disease, a new study has found.

People with Alzheimer's disease exhibit striking structural changes in the caudate nucleus, a brain structure typically associated with movement disorders such as Parkinson's disease, a new study has found.

The research was presented at Neuroscience 2010, the annual meeting of the Society for Neuroscience, held in San Diego.

"Our finding suggests that Alzheimer's disease produces broader damage in the brain than previously thought, including damage to areas not usually associated with the disease," said lead author Sarah Madsen, a graduate student working with Paul Thompson, PhD, of the University of California, Los Angeles.

For the study, Madsen and her colleagues analyzed the brains of 400 elderly participants. Of this group, 100 were healthy, 100 had diagnosed Alzheimer's disease, and 200 had mild cognitive impairment, a condition that sometimes serves as a precursor to Alzheimer's disease.

Compared with healthy individuals, the caudate nucleus was seven percent smaller in those with Alzheimer's disease and four percent smaller in those with mild cognitive impairment. It was also smaller in older and in overweight individuals.

"Our finding suggests a gradual progression of brain tissue loss in the caudate nucleus as dementia becomes more severe," said Madsen. "This brain area, which is associated with certain forms of learning and memory as well as motor control, is an important factor to consider when studying Alzheimer's disease and in predicting how the disease will progress," she said.

Research was supported by the National Institutes of Health Roadmap for Medical Research and Alzheimer's Disease Neuroimaging Initiative, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, and the Dana Foundation.


Story Source:

The above story is based on materials provided by Society for Neuroscience. Note: Materials may be edited for content and length.


Cite This Page:

Society for Neuroscience. "Brain tissue loss in people with Alzheimer’s disease and mild cognitive impairment." ScienceDaily. ScienceDaily, 29 November 2010. <www.sciencedaily.com/releases/2010/11/101116204550.htm>.
Society for Neuroscience. (2010, November 29). Brain tissue loss in people with Alzheimer’s disease and mild cognitive impairment. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2010/11/101116204550.htm
Society for Neuroscience. "Brain tissue loss in people with Alzheimer’s disease and mild cognitive impairment." ScienceDaily. www.sciencedaily.com/releases/2010/11/101116204550.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins