Featured Research

from universities, journals, and other organizations

It takes two: Double detection key for sensing muscle pain

Date:
November 18, 2010
Source:
Cell Press
Summary:
A new study discovers a molecular mechanism involved in pain associated with muscles. The research provides new insight into what underlies one of the most common, and least understood, forms of human pain.

When cardiac or skeletal muscle is not receiving enough oxygen to meet metabolic demands, a person will experience pain, such as angina, chest pain during a heart attack, or leg pain during a vigorous sprint. This type of pain is called "ischemic" pain and is sensed in the body by receptors on sensory neurons.

It has been suggested that lactic acid, which increases during muscle exertion under conditions where oxygen is low, is a potential mediator of ischemic pain via action at acid sensing channel #3 (ASIC3). However, the acid signal it generates is quite subtle and is unlikely to act alone.

"In our study, we examined whether other compounds that appear during ischemia might work synergistically with acid upon ASIC3," explains senior study author, Dr. Edwin W. McCleskey. "We found that another compound released from ischemic muscle, adenosine tri-phosphate (ATP), works together with acid by increasing the sensitivity of ASIC3 on sensory neurons." Importantly, ATP levels have been shown to rise rapidly outside ischemic muscle cells and synergistic action of ATP and acid has been observed in animal models of ischemia.

The researchers went on to show that ATP binds to a membrane purine receptor, called P2X, and that P2X and ASIC appear to form a molecular complex that serves to sensitize ASIC to acid. "Taken together, our results help to explain the paradox that acid appears incapable of triggering ischemic pain by itself yet buffering acid severely decreases sensory detection of ischemic pain," concludes Dr. McCleskey. "ATP, which is released from oxygen-deprived contracting muscle, increases the ability of ASICs to respond to a slight decrease in pH."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "It takes two: Double detection key for sensing muscle pain." ScienceDaily. ScienceDaily, 18 November 2010. <www.sciencedaily.com/releases/2010/11/101117121757.htm>.
Cell Press. (2010, November 18). It takes two: Double detection key for sensing muscle pain. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2010/11/101117121757.htm
Cell Press. "It takes two: Double detection key for sensing muscle pain." ScienceDaily. www.sciencedaily.com/releases/2010/11/101117121757.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins