Featured Research

from universities, journals, and other organizations

How mom's health may increase risk of kidney disease

Date:
November 21, 2010
Source:
American Society of Nephrology
Summary:
Children with chronic kidney disease are more likely to have mothers who were obese or had diabetes during pregnancy, according to a new study.

Children with Chronic Kidney Disease (CKD) are more likely to have mothers who were obese or had diabetes during pregnancy, according to a study presented at the American Society of Nephrology's 43rd Annual Meeting and Scientific Exposition, by Christine W. Hsu, MD (University of Washington, Seattle) and colleagues.

The study included more than 4,000 patients with childhood CKD -- diagnosed at age 21 or younger -- in Washington State. These patients were compared to more than 20,000 healthy children to evaluate possible relationships between a pregnant woman having diabetes, being obese or overweight, and the risk of her child developing CKD anytime during infancy, childhood, or adolescence.

The overall rate of childhood CKD was approximately 0.26 percent -- about 1 case per 400 live births. When investigators adjusted for length of gestation, CKD risk was 69 percent higher for children whose mothers had diabetes before pregnancy. For children whose mothers developed diabetes during pregnancy (gestational diabetes), there was a 28 percent increase in CKD risk. Children of obese mothers demonstrated a 22 percent increase in CKD risk.

When specific causes of kidney disease were analyzed, children whose mothers had diabetes before pregnancy had nearly a 700 percent increase in the risk of kidney-related birth defects (renal aplasia/dysplasia). "Developmental abnormalities of the kidney and urinary tract are the most common cause of childhood CKD," Hsu explains.

The risk of urinary blockage (obstructive uropathy) -- which can lead to CKD -- was increased by 34 percent for children whose mothers had gestational diabetes, 23 percent in those whose mothers were obese, and 21 percent in those whose mothers were overweight but not obese.

In adults, CKD is often related to medical conditions like diabetes and high blood pressure. In contrast, according to Hsu, "Development of childhood CKD may be programmed prenatally." Few studies have looked at possible risk factors for CKD development before adulthood.

"Our research shows that childhood CKD is modestly associated with maternal diabetes and maternal overweight or obesity, with the strongest association between abnormal kidney development and maternal diabetes," says Hsu. "Previous studies have demonstrated that maternal diabetes is associated with an increased risk of general congenital abnormalities. However, with strict control of maternal diabetes, the rate of congenital malformations is similar to that of non-diabetic mothers."

The new results raise the possibility that stricter control of diabetes and weight control during pregnancy could decrease children's risk of developing CKD. "However, this would have to be evaluated in future research," says Hsu.

The study had some limitations related to the fact that it used Washington State birth records linked to a hospital discharge database. As a result, it could only identify children with CKD who were hospitalized and had kidney disease listed in their hospital discharge diagnoses. The study definition of CKD was also broad, and the results are being reanalyzed with a stricter CKD definition. Furthermore, conclusions regarding cause and effect are not possible due to the case control design of the study.

Study co-authors include Kalani Yamamoto, MD, Rohan Henry, MD, Jordan Symons, MD, and Anneclaire De Roos, PhD (University of Washington).


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Cite This Page:

American Society of Nephrology. "How mom's health may increase risk of kidney disease." ScienceDaily. ScienceDaily, 21 November 2010. <www.sciencedaily.com/releases/2010/11/101121122545.htm>.
American Society of Nephrology. (2010, November 21). How mom's health may increase risk of kidney disease. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2010/11/101121122545.htm
American Society of Nephrology. "How mom's health may increase risk of kidney disease." ScienceDaily. www.sciencedaily.com/releases/2010/11/101121122545.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins