Featured Research

from universities, journals, and other organizations

Understanding the role of the protein RyR2 in the heart's response to stress

Date:
November 22, 2010
Source:
Journal of Clinical Investigation
Summary:
The heart beats stronger and faster in situations of stress. If the stress is experienced for only a short time it promotes the fight-or-flight response that enables us to endure physical and emotional exercise, but if it is prolonged it leads to heart failure. Two new reports provide new insight into the mechanisms underlying the response of the mouse heart to the stress.

The heart beats stronger and faster in situations of stress. If the stress is experienced for only a short time it promotes the fight-or-flight response that enables us to endure physical and emotional exercise, but if it is prolonged it leads to heart failure. Two reports from the laboratory of Andrew Marks, at Columbia University, New York, provide new insight into the mechanisms underlying the response of the mouse heart to the stress.

Previous data from Marks' laboratory has indicated that a key part of the response of the heart to prolonged stress is the modification (by phosphorylation on building block serine 2808) of the protein RyR2. In the first of the new reports, Marks and colleagues generated mice in which serine 2808 was replaced with a building block that cannot be phosphorylated and found that their hearts did not beat stronger and faster in response to a chemical substitute for short term stress.

Thus, they conclude that phosphorylation of RyR2 at serine 2808 is important for the short-term response to stress, the fight-or-flight response. In the second paper, they generated mice in which serine 2808 was replaced with a building block that mimics phosphorylated serine. These mice developed heart problems as they aged that could be mitigated with a beta-blocker (the main drugs used to treat heart failure). Thus, Marks and colleagues conclude that one of the mechanisms by which beta-blockers benefit patients with heart failure is by targeting phosphorylated RyR2.

In an accompanying commentary, Thomas Eschenhagen, at the University Medical Center Hamburg Eppendorf, Germany, discusses how the new data generated by Marks and colleagues might help resolve controversies in the field.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jian Shan, Alexander Kushnir, Matthew J. Betzenhauser, Steven Reiken, Jingdong Li, Stephan E. Lehnart, Nicolas Lindegger, Marco Mongillo, Peter J. Mohler, Andrew R. Marks. Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI32726

Cite This Page:

Journal of Clinical Investigation. "Understanding the role of the protein RyR2 in the heart's response to stress." ScienceDaily. ScienceDaily, 22 November 2010. <www.sciencedaily.com/releases/2010/11/101122121635.htm>.
Journal of Clinical Investigation. (2010, November 22). Understanding the role of the protein RyR2 in the heart's response to stress. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2010/11/101122121635.htm
Journal of Clinical Investigation. "Understanding the role of the protein RyR2 in the heart's response to stress." ScienceDaily. www.sciencedaily.com/releases/2010/11/101122121635.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com
The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins