Featured Research

from universities, journals, and other organizations

Monitoring wear-and-tear in helicopters, and also in hips, knees and ankles, too

Date:
November 24, 2010
Source:
American Friends of Tel Aviv University
Summary:
A new technique, "bio-ferrography," can better diagnose diseases, determine drug efficacy, and ascertain the condition of orthopedic implants in our own fragile bodies, according to an expert.

Ferrography, a practice used by the American and Israeli air forces to monitor the condition of machinery, extracts tiny iron particles from lubricants such as oil and grease to analyze wear in machines. Determining whether a system requires preventative maintenance can be the key to preventing catastrophic failure.

Now Tel Aviv University scientists are exploring a modification of this technique for human analysis -- called "bio-ferrography" -- to diagnose diseases in their early stages, determine the efficacy of drugs, and ascertain the condition of orthopedic implants.

Prof. Noam Eliaz, head of Tel Aviv University's Materials and Nanotechnologies Program, says bio-ferrography has the potential to help develop better medications and better implants, and to diagnose the development of diseases, including cancer, at a very early stage.

The research was recently published in a three-part series in the journal Acta Biomaterialia.

Wear of cartilage and bone

Osteoarthritis is characterized by damage to the cartilage in the joints. In severe cases, the cartilage is degraded to the point where bones rub together, which leads to pain and limited movement, says Prof. Eliaz. X-rays, the common diagnostic tool for osteoarthritis, are often insufficient to determine the precise level of the disease. But bio-ferrography can be used for early detection of the disease in a more objective and quantitative way, he explains.

To test the extent of damage to the joints, the researchers use a bio-ferrograph, an apparatus that allows magnetic isolation of target cells or tissues. They capture magnetically-labelled bone and cartilage particles from the synovial fluids extracted from patients' joints, count them, then analyze their chemical composition, shapes and dimensions. The number and dimensions of the wear particles can be correlated to the level of disease, while their chemical composition and shape can indicate from which histological layer of cartilage they originated.

The approach is objective, quantitative, selective and sensitive, allowing for the capture of nanometer-sized particles. "We have been able to detect wear particles even at an early stage of disease, when orthopedists could not identify any damage to the joint by X-ray imaging," explains Prof. Eliaz.

Assessing drugs and implants

The system can also be used to rank the effectiveness of medications in an objective and timely manner. For example, Prof. Eliaz and his team did a study on a common drug called Hyaluronan, which is applied to the knees of patients suffering from osteoarthritis in a series of four injections. Before each of four injections, the researchers collected joint fluids and analyzed the fragments of cartilage and bone to determine whether the medication was able to slow down or prevent cartilage deterioration.

Prof. Eliaz's bio-ferrograph showed a reduction in the concentrations of both cartilage and bone particles during treatment, with the best results appearing after two and three injections. After the fourth injection, however, the concentration of wear particles increased. This finding may eventually lead to the elimination of the fourth injection in the series, he says, reducing both the discomfort to the patient and the associated costs.

According to Prof. Eliaz, bio-ferrography has an additional application in the field of orthopedic implants. It can be used to predict the lifespan of artificial joints during the research and development stage, and later to monitor their degradation in the body and help physicians decide whether to replace them if a catastrophic failure looms.

"We can use this technology at the design stage to determine how new geometries, dimensions and materials affect the implant's functionality," says Prof. Eliaz. "Even after implantation, doctors can test synovial fluids to determine whether an implant is eroding, and at what rate."


Story Source:

The above story is based on materials provided by American Friends of Tel Aviv University. Note: Materials may be edited for content and length.


Cite This Page:

American Friends of Tel Aviv University. "Monitoring wear-and-tear in helicopters, and also in hips, knees and ankles, too." ScienceDaily. ScienceDaily, 24 November 2010. <www.sciencedaily.com/releases/2010/11/101123151725.htm>.
American Friends of Tel Aviv University. (2010, November 24). Monitoring wear-and-tear in helicopters, and also in hips, knees and ankles, too. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2010/11/101123151725.htm
American Friends of Tel Aviv University. "Monitoring wear-and-tear in helicopters, and also in hips, knees and ankles, too." ScienceDaily. www.sciencedaily.com/releases/2010/11/101123151725.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins