Featured Research

from universities, journals, and other organizations

Reliable culture of human embryonic stem cells

Date:
November 27, 2010
Source:
The Biochemical Society
Summary:
Human embryonic stem cells have enormous potential for use in pharmaceutical development and therapeutics; however, to realize this potential there is a requirement for simple and reproducible cell culture methods that provide adequate numbers of cells of suitable quality.

Human embryonic stem cells have enormous potential for use in pharmaceutical development and therapeutics; however, to realize this potential there is a requirement for simple and reproducible cell culture methods that provide adequate numbers of cells of suitable quality.

A team of researchers at the University of Glasgow and Heriot-Watt University, Edinburgh, have discovered a new way of blocking the spontaneous differentiation of stem cells by using the compound erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA). As explained by Peter Burton and colleagues in their paper published in the ChemBio Knowledge Environment of the Biochemical Journal, this means that human embryonic stem cells can be maintained in an undifferentiated state whilst remaining capable of differentiating to all cell types in the body, thus realizing their huge potential as research tools and for cell therapies.

Importantly, the EHNA treatment did not 'lock' the stem cells in an undifferentiated state, as the EHNA was removed, the cells were capable of multi-lineage differentiation.

The researchers note that EHNA is a robust, stable compound, readily prepared from commercially available starting materials at low cost in just two synthetic steps.

Bart Vanhaesebroeck, Deputy Chair for the BJ ChemBio Knowledge Environment, said: said "These findings have immense potential implications for bringing stem cell therapies closer to the clinic."


Story Source:

The above story is based on materials provided by The Biochemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Peter Burton, David Adams, Achamma Abraham, Robert Allcock, Zhong Jiang, Angela McCahill, Jane Gilmour, John McAbney, Alexander Kaupisch, Nicole Kane, George Baillie, Andrew Baker, Graeme Milligan, Miles Houslay, Joanne Mountford. Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells. Biochemical Journal, 2010; DOI: 10.1042/BJ20100726

Cite This Page:

The Biochemical Society. "Reliable culture of human embryonic stem cells." ScienceDaily. ScienceDaily, 27 November 2010. <www.sciencedaily.com/releases/2010/11/101126094456.htm>.
The Biochemical Society. (2010, November 27). Reliable culture of human embryonic stem cells. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2010/11/101126094456.htm
The Biochemical Society. "Reliable culture of human embryonic stem cells." ScienceDaily. www.sciencedaily.com/releases/2010/11/101126094456.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) — Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) — A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) — More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) — Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins