Featured Research

from universities, journals, and other organizations

Reliable culture of human embryonic stem cells

Date:
November 27, 2010
Source:
The Biochemical Society
Summary:
Human embryonic stem cells have enormous potential for use in pharmaceutical development and therapeutics; however, to realize this potential there is a requirement for simple and reproducible cell culture methods that provide adequate numbers of cells of suitable quality.

Human embryonic stem cells have enormous potential for use in pharmaceutical development and therapeutics; however, to realize this potential there is a requirement for simple and reproducible cell culture methods that provide adequate numbers of cells of suitable quality.

A team of researchers at the University of Glasgow and Heriot-Watt University, Edinburgh, have discovered a new way of blocking the spontaneous differentiation of stem cells by using the compound erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA). As explained by Peter Burton and colleagues in their paper published in the ChemBio Knowledge Environment of the Biochemical Journal, this means that human embryonic stem cells can be maintained in an undifferentiated state whilst remaining capable of differentiating to all cell types in the body, thus realizing their huge potential as research tools and for cell therapies.

Importantly, the EHNA treatment did not 'lock' the stem cells in an undifferentiated state, as the EHNA was removed, the cells were capable of multi-lineage differentiation.

The researchers note that EHNA is a robust, stable compound, readily prepared from commercially available starting materials at low cost in just two synthetic steps.

Bart Vanhaesebroeck, Deputy Chair for the BJ ChemBio Knowledge Environment, said: said "These findings have immense potential implications for bringing stem cell therapies closer to the clinic."


Story Source:

The above story is based on materials provided by The Biochemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Peter Burton, David Adams, Achamma Abraham, Robert Allcock, Zhong Jiang, Angela McCahill, Jane Gilmour, John McAbney, Alexander Kaupisch, Nicole Kane, George Baillie, Andrew Baker, Graeme Milligan, Miles Houslay, Joanne Mountford. Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells. Biochemical Journal, 2010; DOI: 10.1042/BJ20100726

Cite This Page:

The Biochemical Society. "Reliable culture of human embryonic stem cells." ScienceDaily. ScienceDaily, 27 November 2010. <www.sciencedaily.com/releases/2010/11/101126094456.htm>.
The Biochemical Society. (2010, November 27). Reliable culture of human embryonic stem cells. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2010/11/101126094456.htm
The Biochemical Society. "Reliable culture of human embryonic stem cells." ScienceDaily. www.sciencedaily.com/releases/2010/11/101126094456.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) — Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) — Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) — According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) — The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins