Nov. 30, 2010 Gold nanoparticles, tiny pieces of gold so small that they can't be seen by the naked eye, are used in electronics, healthcare products and as pharmaceuticals to fight cancer. Despite their positive uses, the process to make the nanoparticles requires dangerous and extremely toxic chemicals. While the nanotechnology industry is expected to produce large quantities of nanoparticles in the near future, researchers have been worried about the environmental impact of the global nanotechnological revolution.
Now, a study by a University of Missouri research team, led by MU scientist Kattesh Katti, curators' professor of radiology and physics in the School of Medicine and the College of Arts and Science, senior research scientist at the University of Missouri Research Reactor and director of the Cancer Nanotechnology Platform, has found a method that could replace nearly all of the toxic chemicals required to make gold nanoparticles. The missing ingredient can be found in nearly every kitchen's spice cabinet -- cinnamon.
The usual method of creating gold nanoparticles utilizes harmful chemicals and acids that are not environmentally safe and contain toxic impurities. In the MU study, Katti and researchers Raghuraman Kannan, the Michael J and Sharon R. Bukstein Distinguished Faculty Scholar in Cancer Research, assistant professor of radiology and director of the Nanoparticle Production Core Facility; and Nripen Chanda, a research associate scientist, mixed gold salts with cinnamon and stirred the mixture in water to synthesize gold nanoparticles. The new process uses no electricity and utilizes no toxic agents.
"The procedure we have developed is non-toxic," Kannan said. "No chemicals are used in the generation of gold nanoparticles, except gold salts. It is a true 'green' process."
"From our work in green nanotechnology, it is clear that cinnamon -- and other species such as herbs, leaves and seeds -- will serve as a reservoir of phytochemicals and has the capability to convert metals into nanoparticles," Katti said. "Therefore, our approach to 'green' nanotechnology creates a renaissance symbolizing the indispensable role of Mother Nature in all future nanotechnological developments."
During the study, the researchers found that active chemicals in cinnamon are released when the nanoparticles are created. When these chemicals, known as phytochemicals, are combined with the gold nanoparticles, they can be used for cancer treatment. The phytochemicals can enter into cancer cells and assist in the destruction or imaging of cancer cells, Katti said.
"Our gold nanoparticles are not only ecologically and biologically benign, they also are biologically active against cancer cells," Katti said.
As the list of applications for nanotechnology grows in areas such as electronics, healthcare products and pharmaceuticals, the ecological implications of nanotechnology also grow. When considering the entire process from development to shipping to storage, creating gold nanoparticles with the current process can be incredibly harmful to the environment, Chanda said.
"On one hand, you are trying to create a new, useful technology. However, continuing to ignore the environmental effects is detrimental to the progress," Kannan said.
The study was published this fall in Pharmaceutical Research.
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- Nripen Chanda, Ravi Shukla, Ajit Zambre, Swapna Mekapothula, Rajesh R. Kulkarni, Kavita Katti, Kiran Bhattacharyya, Genevieve M. Fent, Stan W. Casteel, Evan J. Boote, John A. Viator, Anandhi Upendran, Raghuraman Kannan, Kattesh V. Katti. An Effective Strategy for the Synthesis of Biocompatible Gold Nanoparticles Using Cinnamon Phytochemicals for Phantom CT Imaging and Photoacoustic Detection of Cancerous Cells. Pharmaceutical Research, 2010; DOI: 10.1007/s11095-010-0276-6
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