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Alpha-2 integrin: A protein predictor of tumor spread?

Date:
December 6, 2010
Source:
Journal of Clinical Investigation
Summary:
A new study suggests that decreased expression of the protein alpha-2 integrin is predictive of tumor dissemination to distant sites and decreased survival in individuals with either breast or prostate cancer.

Mary Zutter and colleagues, at Vanderbilt University Medical Center, Nashville, have generated data that lead them to suggest that decreased expression of the protein alpha-2 integrin is predictive of tumor dissemination to distant sites and decreased survival in individuals with either breast or prostate cancer.

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The researchers first studied the role of the protein alpha-2-beta-1 integrin (which is composed of the alpha-2 integrin protein and the beta-1 integrin protein) in cancer initiation and progression using a clinically relevant, spontaneous mouse model of breast cancer progression and metastasis (spread). Their data indicated that alpha-2-beta-1 integrin suppressed metastasis.

To investigate whether the data had any immediate clinical applicability, a systematic analysis of microarray databases of human breast and prostate cancer was performed. The results of this analysis showed that decreased expression of the gene responsible for generating alpha-2 integrin was predictive of metastasis and decreased survival, leading to the suggestion that alpha-2 integrin expression could be a useful biomarker of metastatic potential and patient survival.

The research is published in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. norma E. Ramirez, Zhonghua Zhang, Aasakiran Madamanchi, Kelli L. Boyd, Lynda D. O’Rear, Abudi Nashabi, Zhengzi Li, William D. Dupont, Andries Zijlstra and Mary M. Zutter. The α2β1 integrin is a metastasis suppressor in mouse models and human cancer. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI42328

Cite This Page:

Journal of Clinical Investigation. "Alpha-2 integrin: A protein predictor of tumor spread?." ScienceDaily. ScienceDaily, 6 December 2010. <www.sciencedaily.com/releases/2010/12/101206135406.htm>.
Journal of Clinical Investigation. (2010, December 6). Alpha-2 integrin: A protein predictor of tumor spread?. ScienceDaily. Retrieved January 28, 2015 from www.sciencedaily.com/releases/2010/12/101206135406.htm
Journal of Clinical Investigation. "Alpha-2 integrin: A protein predictor of tumor spread?." ScienceDaily. www.sciencedaily.com/releases/2010/12/101206135406.htm (accessed January 28, 2015).

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