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Sleep deprivation eliminates fear generalization: New way to treat PTSD?

Date:
December 7, 2010
Source:
Elsevier
Summary:
We commonly think of sleep as a healing process that melts away the stresses of the day, preparing us to deal with new challenges. Research has also shown that sleep plays a crucial role in the development of memories. Now, a new study reveals that sleep deprivation can eliminate fear-associated memories, suggesting new approaches to treating posttraumatic stress disorder (PTSD).

We commonly think of sleep as a healing process that melts away the stresses of the day, preparing us to deal with new challenges. Research has also shown that sleep plays a crucial role in the development of memories.

An important component of anxiety disorders, including posttraumatic stress disorder (PTSD), is the formulation of memories associated with fear.

Therefore, researchers decided to evaluate whether sleep deprivation after exposure to an aversive event might eliminate the associated fear, due to the lack of memory consolidation that would typically occur during sleep.

They evaluated healthy volunteers who were shown video clips of both safe driving and unexpected motor vehicle accidents. Half of the volunteers were then deprived of sleep while the other half received a normal night's sleep.

Later testing sessions revealed that sleep deprivation eliminated the fear-associated memories through both fear recognition and physiological fear reactions, suggesting a possible therapy for individuals with PTSD or other anxiety disorders.

Dr. Kenichi Kuriyama, corresponding author, explained: "Sleep deprivation after exposure to a traumatic event, whether intentional or not, may help prevent PTSD. Our findings may help to clarify the functional role of acute insomnia and to develop a prophylactic strategy of sleep restriction for prevention of PTSD."

"It would be nice if the benefits of sleep deprivation upon fear learning could be produced more easily for survivors of extreme stress," noted John Krystal, M.D., Editor of Biological Psychiatry and Professor and Chair of Psychiatry at Yale University. "New insights into the neurobiology of sleep dependent learning may make it possible for these people to take a medication that disrupts this process while leaving restorative elements of sleep intact."

Further research is necessary, but these findings indicate that sleep deprivation is a promising avenue for the possible treatment and prevention of PTSD.


Story Source:

The above story is based on materials provided by Elsevier. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kenichi Kuriyama, Takahiro Soshi, and Yoshiharu Kim. Sleep Deprivation Facilitates Extinction of Implicit Fear Generalization and Physiological Response to Fear. Biological Psychiatry, Volume 68, Number 11

Cite This Page:

Elsevier. "Sleep deprivation eliminates fear generalization: New way to treat PTSD?." ScienceDaily. ScienceDaily, 7 December 2010. <www.sciencedaily.com/releases/2010/12/101207112446.htm>.
Elsevier. (2010, December 7). Sleep deprivation eliminates fear generalization: New way to treat PTSD?. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2010/12/101207112446.htm
Elsevier. "Sleep deprivation eliminates fear generalization: New way to treat PTSD?." ScienceDaily. www.sciencedaily.com/releases/2010/12/101207112446.htm (accessed April 18, 2014).

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