Featured Research

from universities, journals, and other organizations

Obese women with ER-positive/HER2-negative breast cancer have poorer survival rates, study finds

Date:
December 9, 2010
Source:
American Association for Cancer Research
Summary:
Obesity was associated with worse overall and disease-free survival in women with operable breast cancer treated with adjuvant chemotherapy, but for the first time, researchers observed this finding in only a specific subset of patients -- those with estrogen receptor (ER)-positive/HER2-negative disease.

Obesity was associated with worse overall and disease-free survival in women with operable breast cancer treated with adjuvant chemotherapy, but for the first time, researchers observed this finding in only a specific subset of patients -- those with estrogen receptor (ER)-positive/HER2-negative disease.

About one third of all adults in the United States are obese, posing a major public health problem because of obesity's association with an increased risk of diabetes and heart disease. This study identified a new hazard associated with obesity.

Results were presented at the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium, held Dec. 8-12, 2010.

"We were surprised to find that there was no evidence that this finding played out in the other breast cancer subtypes -- it's mainly a phenomenon that we seem to be seeing those with ER-positive/HER2-negative disease," said Joseph A. Sparano, M.D., professor of medicine and women's health at Albert Einstein Medical College of Medicine and associate chairman of the department of oncology at Montefiore Medical Center in Bronx, N.Y.

"Our results may be explained by the fact that obesity is associated with hyperinsulinemia, which may drive the growth of estrogen-dependent tumors," said Sparano.

Sparano and colleagues conducted a retrospective study to evaluate the effect of obesity on the outcomes of three Eastern Cooperative Oncology Group trials: E1199, E5188 and E3189. All three trials involved doxorubicin/cyclophosphamide and other agents.

The researchers first evaluated the relationship between body mass index (BMI) and disease-free survival and overall survival in the E1199 trial. Results showed a nonsignificant trend toward worse disease-free survival and overall survival for the obese patients compared with others.

However, after evaluating these data by breast cancer subtype, obese women with ER and/or progesterone receptor (PR)-positive/HER2-negative disease had significantly worse disease-free survival and overall survival. The same effect was not seen in women with HER2-positive and triple-negative disease.

After this initial finding was seen in the E1199 trial, the research team attempted to validate these findings in two other trials, one of which included only ER-positive disease (E5188) and a second that included only ER-negative disease. The results held up in these two other studies -- obesity was associated with worse outcomes in patients with ER-positive disease in the E5188 trial, but only in patients with ER-negative disease treated in the E3189 trial.

"If validated in other studies, this finding provides strong rationale for trying to identify potential causes, and prospectively evaluate intervention strategies designed to reduce their risk of recurrence," Sparano said.

The researchers plan additional studies to evaluate the relationship between obesity and tumor gene expression, and to identify other host factors that may be associated with recurrence, such as insulin and other growth-factor levels.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Obese women with ER-positive/HER2-negative breast cancer have poorer survival rates, study finds." ScienceDaily. ScienceDaily, 9 December 2010. <www.sciencedaily.com/releases/2010/12/101209101346.htm>.
American Association for Cancer Research. (2010, December 9). Obese women with ER-positive/HER2-negative breast cancer have poorer survival rates, study finds. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2010/12/101209101346.htm
American Association for Cancer Research. "Obese women with ER-positive/HER2-negative breast cancer have poorer survival rates, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/12/101209101346.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins