Featured Research

from universities, journals, and other organizations

Protein restores learning, memory in Alzheimer's mouse model

Date:
December 14, 2010
Source:
University of Texas Health Science Center at San Antonio
Summary:
New studies point to a way to reverse effects of the memory-robbing Alzheimer's disease.

Scientists at the UT Health Science Center San Antonio restored learning and memory in an Alzheimer's disease mouse model by increasing a protein called CBP. Salvatore Oddo, Ph.D., of the university's Department of Physiology and Barshop Institute for Longevity and Aging Studies, said this is the first proof that boosting CBP, which triggers the production of other proteins essential to creating memories, can reverse Alzheimer's effects.

The finding, reported this week in Proceedings of the National Academy of Sciences, provides a novel therapeutic target for development of Alzheimer's medications, Dr. Oddo said. Alzheimer's and other dementias currently impair 5.3 million Americans, including more than 340,000 Texans.

Alzheimer's pathology

In patients with Alzheimer's disease, accumulation of a protein called amyloid-β (Aβ) blocks memory formation by destroying synapses, the sites where neurons share information. Autopsies of the brains of some Alzheimer's patients also reveal tangles caused by a protein called tau.

Enhancing CBP does not alter the Aβ or tau physiology but operates on a different recovery mechanism: It restores activity of a protein called CREB and increases levels of another protein called brain-derived neurotrophic factor (BDNF).

Enhancing signals

"One way by which CBP could work is by setting off a domino effect among proteins that carry signals from the synapse to the nucleus of the neuron," Dr. Oddo said. "Getting signals to the nucleus is necessary for long-term memory."

A viral vehicle

The research team engineered a harmless virus to deliver CBP to the hippocampus in the temporal lobe. The hippocampus is the brain's key structure for learning and memory. At 6 months of age, when the CBP delivery took place, the specially bred mice were at the onset of Alzheimer's-like deficits. Learning and memory were evaluated in a water maze that required mice to remember the location of an exit platform. The mice treated with CBP were compared to diseased mice that received only placebo and to normal, healthy control mice.

Identical to healthy mice

Efficiency in escaping the maze served as signs of learning and memory. In the Alzheimer's mouse model, performance of the Alzheimer's mice treated with enhanced CBP was identical to the healthy mice, whereas the placebo-treated Alzheimer's mice lagged far behind.


Story Source:

The above story is based on materials provided by University of Texas Health Science Center at San Antonio. Note: Materials may be edited for content and length.


Journal Reference:

  1. Antonella Caccamo, Monica A. Maldonado, Alex F. Bokov, Smita Majumder and Salvatore Oddo. CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease. PNAS, December 13, 2010 DOI: 10.1073/pnas.1012851108

Cite This Page:

University of Texas Health Science Center at San Antonio. "Protein restores learning, memory in Alzheimer's mouse model." ScienceDaily. ScienceDaily, 14 December 2010. <www.sciencedaily.com/releases/2010/12/101213151401.htm>.
University of Texas Health Science Center at San Antonio. (2010, December 14). Protein restores learning, memory in Alzheimer's mouse model. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2010/12/101213151401.htm
University of Texas Health Science Center at San Antonio. "Protein restores learning, memory in Alzheimer's mouse model." ScienceDaily. www.sciencedaily.com/releases/2010/12/101213151401.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins