Featured Research

from universities, journals, and other organizations

Link between cholesterol compound and multiple sclerosis unlikely, researchers say

Date:
December 16, 2010
Source:
American Society for Biochemistry and Molecular Biology
Summary:
New research findings indicate that compounds called oxysterols are not present in any significant amount in multiple sclerosis patients, contradicting a previous study that suggested that some of these cholesterol metabolites were associated with MS and could be used as diagnostic tools in the clinic.

New research findings appearing in the January Journal of Lipid Research indicate that compounds called oxysterols are not present in any significant amount in multiple sclerosis patients, contradicting a previous study that suggested that some of these cholesterol metabolites were associated with MS and could be used as diagnostic tools in the clinic.

Oxysterols are somewhat controversial in science; while some laboratory experiments suggest these steroid molecules may be biologically important, they are present in only trace amounts in the blood, and studies in living animals or humans have not convincingly proven a definitive role.

Therefore, there was great interest when a study published last year in the journal Nature Immunology reported that two oxysterols, known as 15HC and 15KC, were increased more than three-fold in the blood of MS patients, and that these oxysterols could be associated with the development of the disease.

Spurred by those findings, Ingemar Björkhem and colleagues at Sweden's Karolinska Institutet decided to perform their own analysis of blood samples using a combination of gas chromatography and mass spectrometry, which vaporizes the samples and separates the component parts to allow for a thorough separation of all molecules; thus they could identify 15HC and 15KC levels even at low concentrations.

Despite numerous efforts, though, Björkhem and colleagues failed to find any meaningful 15HC or 15KC oxysterol levels in blood of healthy individuals or MS patients.

To ensure the oxysterols were not being lost or metabolized somewhere along the experimental chain, they also ran blood samples with pre-loaded oxysterols and recovered almost 100 percent of the loaded amount, demonstrating that the protocol was not the problem; any 15HC or 15KC present in the patient samples would have been found.

Björkhem notes that given the conflicting results of recent studies, the potential role of oxysterols in multiple sclerosis needs to be reconsidered.

In a commentary accompanying the new paper by Björkhem's team, William Griffiths and Yuqin Wang of the U.K.'s Swansea University, who were not involved in either study, said they suspect the original research team who reported the oxysterol discovery in 2009 "incorrectly identified [the compounds] in plasma, in which case their data would suggest that some unidentified lipids are increased in the circulation of patients with (MS)."

"It is important that these compounds are now identified," they added.


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Journal References:

  1. I. Bjorkhem, A. Lovgren-Sandblom, F. Piehl, M. Khademi, H. Pettersson, V. Leoni, T. Olsson, U. Diczfalusy. High levels of 15-oxygenated steroids in circulation of patients with multiple sclerosis: fact or fiction? The Journal of Lipid Research, 2010; 52 (1): 170 DOI: 10.1194/jlr.D011072
  2. W. J. Griffiths, Y. Wang. Are 15-oxygenated sterols present in the human circulation? The Journal of Lipid Research, 2010; 52 (1): 4 DOI: 10.1194/jlr.E012088

Cite This Page:

American Society for Biochemistry and Molecular Biology. "Link between cholesterol compound and multiple sclerosis unlikely, researchers say." ScienceDaily. ScienceDaily, 16 December 2010. <www.sciencedaily.com/releases/2010/12/101215163756.htm>.
American Society for Biochemistry and Molecular Biology. (2010, December 16). Link between cholesterol compound and multiple sclerosis unlikely, researchers say. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2010/12/101215163756.htm
American Society for Biochemistry and Molecular Biology. "Link between cholesterol compound and multiple sclerosis unlikely, researchers say." ScienceDaily. www.sciencedaily.com/releases/2010/12/101215163756.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) — As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) — Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
U.S. Food Makers Surpass Calorie-Cutting Pledge

U.S. Food Makers Surpass Calorie-Cutting Pledge

Newsy (Sep. 18, 2014) — Sixteen large food and beverage companies in the United States that committed to cut calories in their products far surpassed their target. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) — Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins