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Dampening inflammation with aspirin

Date:
January 5, 2011
Source:
Journal of Clinical Investigation
Summary:
Upon microbe clearance from the body or completion of wound healing, protective inflammatory responses must be dampened down. One set of molecules known to play a role in resolving the inflammatory response is the E-series resolvins. While analyzing the blood of several individuals to investigate the pathway by which E-series resolvins are generated, researchers have identified a new 18S E-series resolvin, which could be generated from aspirin.
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Inflammation is a protective response to invading microbes and tissue damage. Upon microbe clearance from the body or completion of wound healing, the inflammatory response must be dampened down. One set of molecules known to play a role in resolving the inflammatory response is the E-series resolvins.

While analyzing the blood of several individuals to investigate the pathway by which E-series resolvins are generated, Charles Serhan and colleagues, at Harvard Medical School, Boston, identified a new 18S E-series resolvin.

Importantly, the new resolvin reduced levels of pro-inflammatory molecules and cells in a mouse model of inflammation caused by the bacterium E. coli. Further, as the new resolvin could be generated from aspirin, the authors suggest that this molecule could contribute to the beneficial effects of aspirin.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sungwhan F. Oh, Padmini S. Pillai, Antonio Recchiuti, Rong Yang, Charles N. Serhan. Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation. Journal of Clinical Investigation, 2011; DOI: 10.1172/JCI42545

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Journal of Clinical Investigation. "Dampening inflammation with aspirin." ScienceDaily. ScienceDaily, 5 January 2011. <www.sciencedaily.com/releases/2011/01/110104133858.htm>.
Journal of Clinical Investigation. (2011, January 5). Dampening inflammation with aspirin. ScienceDaily. Retrieved May 24, 2015 from www.sciencedaily.com/releases/2011/01/110104133858.htm
Journal of Clinical Investigation. "Dampening inflammation with aspirin." ScienceDaily. www.sciencedaily.com/releases/2011/01/110104133858.htm (accessed May 24, 2015).

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