Featured Research

from universities, journals, and other organizations

Lab-on-a-chip developed for fast, inexpensive blood tests: Smartphone app next

Date:
January 12, 2011
Source:
University of Rhode Island
Summary:
While most blood tests require shipping a vial of blood to a laboratory for analysis and waiting several days for the results, a new device invented by a team of engineers and students uses just a pinprick of blood in a portable device that provides results in less than 30 minutes. The next step will turn blood testing into a smartphone application.

While most blood tests require shipping a vial of blood to a laboratory for analysis and waiting several days for the results, a new device invented by a team of engineers and students at the University of Rhode Island uses just a pinprick of blood in a portable device that provides results in less than 30 minutes.

"This development is a big step in point-of-care diagnostics, where testing can be performed in a clinic, in a doctor's office, or right at home," said Mohammad Faghri, URI professor of mechanical engineering and the lead researcher on the project. "No longer will patients have to wait anxiously for several days for their test results. They can have their blood tested when they walk into the doctor's office and the results will be ready before they leave."

With the new lab-on-a-chip technology, a drop of blood is placed on a plastic polymer cartridge smaller than a credit card and inserted into a shoebox-sized biosensor containing a miniature spectrometer and piezoelectric micro-pump. The blood travels through the cartridge in tiny channels 500 microns wide to a detection site where it reacts with preloaded reagents enabling the sensor to detect certain biomarkers of disease.

Several patents are pending on the invention.

Compared to similar devices in development elsewhere, the URI system is much smaller, more portable, requires a smaller blood sample, and is less expensive. While the sensor costs about $3,200, each test costs just $1.50, which is the cost for the plastic cartridge and reagents.

The first cartridges the researchers developed focus on the detection of C-reactive proteins (CRP) in the blood, a preferred method for helping doctors assess the risk of cardiovascular and peripheral vascular diseases. From 2002 to 2004 (the only years for which data are available), the number of CRP tests paid for by Medicare tripled from 145,000 to 454,000, and it is estimated that those numbers have quadrupled since then.

Faghri said that additional cartridges can be designed to detect biomarkers of other diseases. The researchers are already working to engineer the device to detect levels of the beta amyloid protein that can be used as a predictor of Alzheimer's disease. The device can also be engineered to detect virulent pathogens, including HIV, hepatitis B and H1N1 (swine) flu.

The next generation of the device will incorporate a hand-held sensor that will reduce manufacturing costs. Faghri also envisions a further miniaturization of the invention that can be adapted as a smartphone application. By embedding the biosensor in the cartridge and using the computer power of the phone, as well as its wireless communication capabilities, Faghri believes that patients may be able to conduct the tests themselves and have the results transmitted immediately to their doctor's office via their phone. Among many other benefits, this should help to significantly reduce health care costs.

"We are already making progress on many of the steps toward the next generation of the system, and it won't be long before we can begin to commercialize it," Faghri said.

In addition to Faghri, the research team includes URI Adjunct Professor Constantine Anagnostopoulos, Postdoctoral Associate Assem Abolmaaty, graduate students Peng Li, Kelly Cook, Jeremy Cogswell, John Jones, Michael Godfrin, Alex Pytka, Assad Akinfolarin, Hong Chen and Toru Yamada, and undergraduate students Admir Monteiro and Nick DiFillipo, as well as Research Associate Stefanie Demming from the Technical Institute of Braunschweig, Germany.

Primary funding for the project was provided by the National Science Foundation through its Partnership for International Research and Education Program.


Story Source:

The above story is based on materials provided by University of Rhode Island. Note: Materials may be edited for content and length.


Cite This Page:

University of Rhode Island. "Lab-on-a-chip developed for fast, inexpensive blood tests: Smartphone app next." ScienceDaily. ScienceDaily, 12 January 2011. <www.sciencedaily.com/releases/2011/01/110110053033.htm>.
University of Rhode Island. (2011, January 12). Lab-on-a-chip developed for fast, inexpensive blood tests: Smartphone app next. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2011/01/110110053033.htm
University of Rhode Island. "Lab-on-a-chip developed for fast, inexpensive blood tests: Smartphone app next." ScienceDaily. www.sciencedaily.com/releases/2011/01/110110053033.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins