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Transforming skin cells into cartilage

Date:
January 17, 2011
Source:
Journal of Clinical Investigation
Summary:
In new research, scientists in Japan used fibroblasts isolated from adult mouse skin, and expressed proteins used to induce pluripotency along with a factor that promotes a chondrocyte fate. The resulting cells resembled chondrocytes and produced cartilage when injected into mice. This may be an important step toward a therapy that will allow the repair of cartilage injury using a patient's own skin cells.
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In new research, Noriyuki Tsumaki and his team at the Osaka University Graduate School of Medicine, used fibroblasts isolated from adult mouse skin, and expressed proteins used to induce pluripotency along with a factor that promotes a chondrocyte fate. The resulting cells resembled chondrocytes and produced cartilage when injected into mice. This may be an important step toward a therapy that will allow the repair of cartilage injury using a patient's own skin cells.

Hyaline cartilage, composed primarily of chondrocytes in an extensive extracellular matrix, makes up the embryonic skeleton and persists in adults at the ends of bones, where it provides shock absorption and lubrication of joints. Hyaline cartilage injury often results in the formation of the scar tissue fibrocartilage or even new bone formation leading to growth impairment or osteoarthritis. However, regeneration of cartilage might be possible if researchers can develop a method to generate new chondrocytes.

In this paper, Noriyuki Tsumaki and his team at the Osaka University Graduate School of Medicine, used fibroblasts isolated from adult mouse skin, and expressed proteins that have previously been used to induce pluripotency along with a factor that promotes a chondrocyte fate. This produced cells with traits that resembled chondrocytes and produced cartilage when injected into mice.

The researchers believe this may be an important step toward a therapy that will allow th e repair of cartilage injury using a patient's own skin cells.

The research appears in the Journal of Clinical Investigation.


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The above post is reprinted from materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kunihiko Hiramatsu, Satoru Sasagawa, Hidetatsu Outani, Kanako Nakagawa, Hideki Yoshikawa and Noriyuki Tsumaki. Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors. Journal of Clinical Investigation, 2011; DOI: 10.1172/JCI44605

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Journal of Clinical Investigation. "Transforming skin cells into cartilage." ScienceDaily. ScienceDaily, 17 January 2011. <www.sciencedaily.com/releases/2011/01/110110121623.htm>.
Journal of Clinical Investigation. (2011, January 17). Transforming skin cells into cartilage. ScienceDaily. Retrieved August 3, 2015 from www.sciencedaily.com/releases/2011/01/110110121623.htm
Journal of Clinical Investigation. "Transforming skin cells into cartilage." ScienceDaily. www.sciencedaily.com/releases/2011/01/110110121623.htm (accessed August 3, 2015).

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