Featured Research

from universities, journals, and other organizations

Remote-controlled capsule endoscope safely examines the stomach

Date:
January 21, 2011
Source:
American Society for Gastrointestinal Endoscopy
Summary:
A new study showed that magnetic maneuvering of a modified capsule endoscope in the stomach of healthy volunteers under clinical conditions is safe, well-tolerated and technically feasible. Maneuverability of the capsule within the stomach was excellent and visualization of the gastric mucosa was satisfactory in the majority of subjects. Apart from a single experiment performed with a supervising flexible gastroscope, this was the first study to use the system in the stomach of healthy subjects.

A study from researchers in Germany showed that magnetic maneuvering of a modified capsule endoscope in the stomach of healthy volunteers under clinical conditions is safe, well-tolerated, and technically feasible. Maneuverability of the capsule within the stomach was excellent and visualization of the gastric mucosa, the inner lining of the stomach, was satisfactory in the majority of subjects. Apart from a single experiment performed with a supervising flexible gastroscope, this was the first study to use the system in the stomach of healthy subjects. The study appears in the January issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE).

Related Articles


Data from prospective studies indicate that gastric cancer screening programs may have a positive impact on mortality associated with the disease. Upper endoscopy is the reference method for the detection of gastric mucosal alterations (changes in the lining of the stomach) and therefore might be the most appropriate screening tool. Unfortunately, some view endoscopy as uncomfortable, and worry about low patient compliance. Capsule endoscopy might offer a more "patient-friendly" alternative. However, conventional capsule endoscopies have shown that visualization of the stomach is highly variable.

A conventional capsule endoscope examines the small intestine using a pill-sized video capsule which has its own lens and light source. The camera takes 50,000-60,000 digital images during the procedure. The system consists of an ingestible pill camera (26 x 11 mm), a data recorder, and computer software for interpretation. Images recorded by the capsule camera are transmitted and stored on a data recorder worn by the patient. The images are downloaded onto a computer, where they are then viewed and interpreted by a specially trained gastroenterologist. A wireless colon capsule for visualizing the colon for screening purposes has been developed, but is not currently FDA approved for use in the U.S.

"To address the problems with a conventional capsule endoscope in visualizing the stomach, a new tool for maneuvering the capsule using an external handheld magnet was developed, allowing targeted investigation of all regions of the stomach," said study lead author Junta Keller, MD, Department of Internal Medicine, University of Hamburg, Hamburg, Germany. "The aim of our study was to evaluate the safety and feasibility of the magnetic maneuvering of a capsule endoscope in a human stomach. We found that the magnetic maneuvering of the capsule was safe and very well-tolerated, with excellent responsiveness of the capsule to movements of the outer magnet so that detailed visualization of the gastric mucosa could be achieved."

Methods

The objective of the study was to assess the safety and efficacy of the manipulation of a modified capsule endoscope with magnetic materials in the human stomach by using a handheld external magnet. Ten healthy volunteers (five men and five women) in an open clinical trial at the Israelitic Hospital in Hamburg, Germany, participated in the study. The magnetic maneuverable capsule (MMC) is a modification of a standard colon capsule with magnetic disks inserted inside one of the domes of the capsule. The MMC is activated by a novel radiofrequency switch (replacing the thermal switch previously used to initiate MMCs) and operates at four frames per second from a single camera. It transmits images to the data recorder via a set of sensors placed on the patient's skin. These can be viewed in real time by using the Real Time Viewer and compiled after the examination into a video by using the RAPID workstation. The external magnet paddle has a single strong magnet.

The study participants swallowed the MMC and sherbet powder to distend the stomach, which flattens the folds of the stomach. The external magnetic paddle was used to manipulate the MMC within the stomach. MMC responsiveness was evaluated on a screen showing the MMC film in real time. The main outcome measurements were safety and tolerability, time the MMC remained in the stomach, its responsiveness to the magnetic paddle, and the area of the stomach lining visualized.

Results

The MMC was always clearly attracted by the magnetic paddle and responded to its movements. In seven participants, maneuverability was graded as excellent because the MMC followed the rotating and tilting movements of the magnetic paddle smoothly. It remained in the stomach for approximately 39 minutes (plus or minus 24 minutes). In seven subjects, both the cardia (part of the stomach immediately adjacent to the esophagus) and the pylorus (part of the stomach through which contents are emptied into the small intestine) were inspected and 75 percent or more of the gastric mucosa was visualized (greater than or equal to 50 percent in all of the remaining subjects). The researchers noted that a learning curve was clearly recognizable (identification of MMC localization, intended movements). Some limitations of the study included small amounts of fluid that blocked the view of an area of the stomach called the fundus and gastric distention was not sufficient to flatten all gastric folds. There were no adverse events.

Study participants completed a questionnaire after the procedure, asking about difficulties swallowing, pain or other complaints. Nine participants reported no complaints and one reported mild complaints of feeling pressure. The researchers concluded that remote control of the MMC in the stomach of healthy volunteers using a handheld magnet is safe and feasible. Responsiveness of the MMC was excellent, and visualization of the stomach lining was good, although not complete, in the majority of subjects. The system appeared to be clinically valuable and should be developed further.


Story Source:

The above story is based on materials provided by American Society for Gastrointestinal Endoscopy. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jutta Keller, Christiane Fibbe, Frank Volke, Jeremy Gerber, Alexander C. Mosse, Meike Reimann-Zawadzki, Elisha Rabinovitz, Peter Layer, Daniel Schmitt, Viola Andresen. Inspection of the human stomach using remote-controlled capsule endoscopy: a feasibility study in healthy volunteers (with videos). Gastrointestinal Endoscopy, 2011; 73 (1): 22 DOI: 10.1016/j.gie.2010.08.053

Cite This Page:

American Society for Gastrointestinal Endoscopy. "Remote-controlled capsule endoscope safely examines the stomach." ScienceDaily. ScienceDaily, 21 January 2011. <www.sciencedaily.com/releases/2011/01/110118122743.htm>.
American Society for Gastrointestinal Endoscopy. (2011, January 21). Remote-controlled capsule endoscope safely examines the stomach. ScienceDaily. Retrieved November 29, 2014 from www.sciencedaily.com/releases/2011/01/110118122743.htm
American Society for Gastrointestinal Endoscopy. "Remote-controlled capsule endoscope safely examines the stomach." ScienceDaily. www.sciencedaily.com/releases/2011/01/110118122743.htm (accessed November 29, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins