Featured Research

from universities, journals, and other organizations

Nanoparticle vaccine protects against stomach flu

Date:
January 20, 2011
Source:
American Society for Microbiology
Summary:
A new vaccine strategy using nanoparticles as carriers may be the key to developing a vaccine against norovirus, one of the most common causes of foodborne disease in the United States.

A new vaccine strategy using nanoparticles as carriers may be the key to developing a vaccine against norovirus, one of the most common causes of foodborne disease in the United States. Researchers from the Cincinnati Children's Hospital Medical Center report promising findings in the January 2011 issue of the Journal of Virology.

Related Articles


The application of nanoparticles as carriers to present small peptide antigens is a growing field within vaccine development. Researchers led by Xi Jason Jiang of Cincinnati Children's Hospital Medical Center, have described a new nanocarrier, called a P particle, which holds promise as a scaffold for a variety of vaccines. In the current study they inserted rotavirus antigen into the P particle, which boosted immune response to rotavirus, as well as norovirus, in mice.

Both rotavirus and norovirus are important causes of acute gastroenteritis. The former causes severe diarrhea in children, and kills an estimated 527,000 worldwide, annually. Norovirus is a notably highly transmissible, and particularly unpleasant flu, which can result in one to three days of vomiting and diarrhea in otherwise healthy adults, and which kills 200,000 children annually.

"The dual vaccine holds promise for controlling gastroenteritis in children," says Jiang.

The P particle's unique feature is the scaffold. The P particle consists of 24 copies of an outer coat protein from norovirus. The beauty of the P particle is that it contains three types of surface loops, which are ideal for presenting a wide variety of antigens. Additionally, it is highly immunogenic and extremely stable, the latter an important quality for use in developing nations. The antigens can easily be inserted during the manufacturing process. Production is a simple matter of expressing the cloned P particle in E. coli.

In addition to the rotavirus antigen, the team has succeeded in inserting a number of antigens into the P particle, varying in size up to more than 200 amino acids. The resulting vaccines have induced significantly stronger immune responses in mice than have free antigens.

Jiang is principal investigator for a five year, $4.1 million grant from the National Institute of Allergy & Infectious Disease (NIAID) that Cincinnati Children's received last May to develop the P particle vaccine against norovirus. "With the unique features of high efficiency, easy production, and low cost, this new platform will find a broad application in the biomedical sciences," says Jiang.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Tan, P. Huang, M. Xia, P.-A. Fang, W. Zhong, M. McNeal, C. Wei, W. Jiang, X. Jiang. Norovirus P Particle, a Novel Platform for Vaccine Development and Antibody Production. Journal of Virology, 2010; 85 (2): 753 DOI: 10.1128/JVI.01835-10

Cite This Page:

American Society for Microbiology. "Nanoparticle vaccine protects against stomach flu." ScienceDaily. ScienceDaily, 20 January 2011. <www.sciencedaily.com/releases/2011/01/110119191230.htm>.
American Society for Microbiology. (2011, January 20). Nanoparticle vaccine protects against stomach flu. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2011/01/110119191230.htm
American Society for Microbiology. "Nanoparticle vaccine protects against stomach flu." ScienceDaily. www.sciencedaily.com/releases/2011/01/110119191230.htm (accessed April 18, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 18, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com
Boy or Girl? Intersex Awareness Is on the Rise

Boy or Girl? Intersex Awareness Is on the Rise

AP (Apr. 17, 2015) At least 1 in 5,000 U.S. babies are born each year with intersex conditions _ ambiguous genitals because of genetic glitches or hormone problems. Secrecy and surgery are common. But some doctors and activists are trying to change things. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins