Featured Research

from universities, journals, and other organizations

Age of onset of puberty predicts adult osteoporosis risk: Later puberty results in lower bone mass

Date:
January 28, 2011
Source:
Children's Hospital Los Angeles
Summary:
Researchers have determined that the onset of puberty was the primary influence on adult bone mineral density, or bone strength.

A team of researchers led by Vicente Gilsanz, MD, PhD, director of Clinical Imaging at The Saban Research Institute of Children's Hospital Los Angeles, determined that the onset of puberty was the primary influence on adult bone mineral density, or bone strength. Length of puberty did not affect bone density.

Reduced bone mineral density leads to osteoporosis, resulting in bones becoming increasingly brittle and at risk for fracture. Osteoporosis is a significant public health issue with the cost of treatment in 2010 estimated at $10 billion. This condition affects 55% of Americans aged 50 and older.

The Bone Mineral Density in Childhood Study is an ongoing multicenter study examining bone development in healthy children and teenagers of both sexes and ethnic groups in the United States. For this analysis, the investigators studied 78 girls and 84 boys who had just entered puberty, until they reached sexual maturity.

"Puberty has a significant role in bone development," explained Dr. Gilsanz. "During this time, bones lengthen and increase in density. At the end of puberty the epiphyseal plates close, terminating the ability of the bones to lengthen. When this occurs, the teenager has reached their maximum adult height and peak bone mass. We found that early puberty was associated with greater bone mass while later puberty resulted in less."

Adolescents with short stature sometimes undergo medical intervention to delay puberty in an effort to achieve greater height. This study indicates that prolonging the growth period by delaying puberty may have unexpected consequences in later life.

The 2000 National Institutes of Health Consensus Development Conference on Osteoporosis Prevention, Diagnosis, and Therapy identified bone mineral deposition during adolescence as a critical determinant of osteoporosis risk later in life. The care of patients with osteoporosis is difficult, and most therapies increase bone density by small amounts yet requires long periods of treatment. In contrast, during puberty large increases in bone density occur over a short period of time.

Given that the rate of decline of bone mass in adulthood is approximately 1% to 2% each year, a 10% to 20% increase in bone density resulting from a natural early puberty corresponds to an additional 10 to 20 years of protection against the normal age-related decline in bone strength.

Collaborators on this study included Tishya Wren, PhD, and James Chalfant, BS, Children's Hospital Los Angeles; John Shepherd, PhD, University of California, San Francisco; Heidi Kalkwarf, PhD, Cincinnati Children's Medical Center; Babette Zemel, PhD, Children's Hospital of Philadelphia; Joan Lappe, PhD, Creighton University; Sharon Oberfield, MD, Columbia University; and Karen Winer, MD, National Institute of Child Health and Development. The article was published in the Journal of Pediatrics.


Story Source:

The above story is based on materials provided by Children's Hospital Los Angeles. Note: Materials may be edited for content and length.


Journal Reference:

  1. Vicente Gilsanz, James Chalfant, Heidi Kalkwarf, Babette Zemel, Joan Lappe, Sharon Oberfield, John Shepherd, Tishya Wren, Karen Winer. Age at Onset of Puberty Predicts Bone Mass in Young Adulthood. The Journal of Pediatrics, 2011; 158 (1): 100 DOI: 10.1016/j.jpeds.2010.06.054

Cite This Page:

Children's Hospital Los Angeles. "Age of onset of puberty predicts adult osteoporosis risk: Later puberty results in lower bone mass." ScienceDaily. ScienceDaily, 28 January 2011. <www.sciencedaily.com/releases/2011/01/110128123531.htm>.
Children's Hospital Los Angeles. (2011, January 28). Age of onset of puberty predicts adult osteoporosis risk: Later puberty results in lower bone mass. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2011/01/110128123531.htm
Children's Hospital Los Angeles. "Age of onset of puberty predicts adult osteoporosis risk: Later puberty results in lower bone mass." ScienceDaily. www.sciencedaily.com/releases/2011/01/110128123531.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins