Featured Research

from universities, journals, and other organizations

New gift from Mother Nature’s medicine chest may help prevent and treat bone diseases

Date:
February 2, 2011
Source:
American Chemical Society
Summary:
One of Mother Nature's latest gifts to medical science is stirring excitement with the discovery that the substance -- obtained from a coral-reef inhabiting cyanobacterium -- appears to be an ideal blueprint for developing new drugs for serious fractures, osteoporosis, and other bone diseases.

One of Mother Nature's latest gifts to medical science is stirring excitement with the discovery that the substance -- obtained from a coral-reef inhabiting cyanobacterium -- appears to be an ideal blueprint for developing new drugs for serious fractures, osteoporosis, and other bone diseases.

That's the conclusion of a study on the substance, Largazole, in the journal ACS Medicinal Chemistry Letters.

By some estimates, more than half of today's medications are in Largazole's family, the "natural products." They come from trees, snails, scorpion venom, soil bacteria, other plants and animals; however, so far only a few come from the ocean. In the report, Jiyong Hong, Seong Hwan Kim, Hendrik Luesch and colleagues indicate that Largazole was derived from and named for marine cyanobacteria that grow in Key Largo, Florida. Largazole, they add, already has attracted scientific attention for its ability to kill cancer cells in laboratory experiments.

Their research in laboratory dishes and test animals showed that Largazole has an unusual dual action on injured or diseased bones. It stimulates a process in the body called osteogenesis, which involves the growth of new bone and the repair of damaged bone. Largazole also blocks the oppose process in which the body naturally breaks down and resorbs bone. Both of those benefits, the scientists found, come from Largazole's effects on proteins called histone deacetylases, which are a sort of master control switch for protein production. Drugs that block histone deacetylases are currently used to treat cancer, and they may have other health benefits as well. The researchers also showed that Largazole mixed with collagen and calcium phosphate, bone components, helped heal fractured bones in laboratory mice and rabbits.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Su-Ui Lee, Han Bok Kwak, Sung-Hee Pi, Hyung-Keun You, Seong Rim Byeon, Yongcheng Ying, Hendrik Luesch, Jiyong Hong, Seong Hwan Kim. In VitroandIn VivoOsteogenic Activity of Largazole. ACS Medicinal Chemistry Letters, 2011; 110126133119097 DOI: 10.1021/ml1002794

Cite This Page:

American Chemical Society. "New gift from Mother Nature’s medicine chest may help prevent and treat bone diseases." ScienceDaily. ScienceDaily, 2 February 2011. <www.sciencedaily.com/releases/2011/02/110202082309.htm>.
American Chemical Society. (2011, February 2). New gift from Mother Nature’s medicine chest may help prevent and treat bone diseases. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2011/02/110202082309.htm
American Chemical Society. "New gift from Mother Nature’s medicine chest may help prevent and treat bone diseases." ScienceDaily. www.sciencedaily.com/releases/2011/02/110202082309.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
U.S. Food Makers Surpass Calorie-Cutting Pledge

U.S. Food Makers Surpass Calorie-Cutting Pledge

Newsy (Sep. 18, 2014) Sixteen large food and beverage companies in the United States that committed to cut calories in their products far surpassed their target. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins