Featured Research

from universities, journals, and other organizations

Low-cost, nanometer-sized drug holds promise for treatment of chronic diabetes and burn wounds

Date:
February 7, 2011
Source:
Hebrew University of Jerusalem
Summary:
A low cost, nanometer-sized drug to treat chronic wounds, such as diabetic foot ulcers or burns, has been developed by a group of scientists from Israel, the U.S. and Japan.

Dr. Yaakov Nahmias is head of the Center for Bioengineering in the Service of Humanity at the Hebrew University of Jerusalem.
Credit: The Hebrew University of Jerusalem

A low cost, nanometer-sizeddrug to treat chronic wounds, such as diabetic foot ulcers or burns, has been developed by a group of scientists from the Hebrew University of Jerusalem, Harvard Medical School and others in the U.S. and Japan.

Diabetes is a rapidly growing medical problem affecting close to 3 percent of the world’s population. Poor blood circulation arising from diabetes often results in skin wounds which do not heal, causing pain, infection and at times amputation of limbs.

Several proteins,called growth factors, have been found to speed up the healing process, however purifyingthese growth factor proteins is veryexpensive, and they do not last long on the injured site.

Now, scientists at the Hebrew University and Harvard involved in the project have used genetic engineering to produce a “robotic” growth factor protein that responds to temperature.Increasingthe temperature causes dozens of these proteins to fold together into a nanoparticle that is more than 200 times smaller than a single hair.

This behaviorgreatly simplifies protein purification, making it very inexpensive to produce. It also enablesthe growth factor to be confined and to remain at theburn or wound site.The scientists refer to their discovery as robotic, since just as robots are machines that respond to their environment by carrying out a specific activity, so too this protein they have developed responds and reacts to heat.

The experimental drug, which ha been developed by the research group as a topical ointment, has been patented and thus far has been used to treat chronic wounds in diabetic mice, dramatically increasing the healing rate. The goal is to proceed to human clinical trials at some future date after future tests and refinements.

An article on the project has been published online in the Proceedings of the National Academy of Sciences. The authors are Dr. Yaakov Nahmias, director of the Center for Bioengineering in the Service of Humanity at the Hebrew University of Jerusalem; Dr. Zaki Megeed, Prof. Robert Sheridan and Prof. Martin L. Yarmush of the Harvard Medical School and Shriners Hospitals for Children; Prof. Piyush Koria of the University of South Florida; and Dr. Hiroshi Yagi and Dr. Yuko Kitagawa of the Keio University School of Medicine in Japan.


Story Source:

The above story is based on materials provided by Hebrew University of Jerusalem. Note: Materials may be edited for content and length.


Journal Reference:

  1. P. Koria, H. Yagi, Y. Kitagawa, Z. Megeed, Y. Nahmias, R. Sheridan, M. L. Yarmush. Self-assembling elastin-like peptides growth factor chimeric nanoparticles for the treatment of chronic wounds. Proceedings of the National Academy of Sciences, 2010; 108 (3): 1034 DOI: 10.1073/pnas.1009881108

Cite This Page:

Hebrew University of Jerusalem. "Low-cost, nanometer-sized drug holds promise for treatment of chronic diabetes and burn wounds." ScienceDaily. ScienceDaily, 7 February 2011. <www.sciencedaily.com/releases/2011/02/110207084325.htm>.
Hebrew University of Jerusalem. (2011, February 7). Low-cost, nanometer-sized drug holds promise for treatment of chronic diabetes and burn wounds. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2011/02/110207084325.htm
Hebrew University of Jerusalem. "Low-cost, nanometer-sized drug holds promise for treatment of chronic diabetes and burn wounds." ScienceDaily. www.sciencedaily.com/releases/2011/02/110207084325.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins